This project is designed to evaluate the molecular markers in patients that are undergoing radiotherapy in serum and urine. This work is prospective and hypothesis generating. In the past year we have initiated an international trial of patients with glioblastoma multiforme (GBM) to determine if urinary vascular endothelial growth factor (VEGF) or matrix metalloproteinase-2 (MMP-2) can help predict outcome. This past year we have worked on standardizing the collection procedures, analysis procedures, and the many biomolecules that could incorrectly alter the VEGF levels and we have published 2 manuscripts on specimen preparation and storage.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
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National Cancer Institute Division of Clinical Sciences
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Krauze, Andra V; Attia, Albert; Braunstein, Steve et al. (2017) Expert consensus on re-irradiation for recurrent glioma. Radiat Oncol 12:194
Krauze, Andra Valentina; Peters, Cord; Cheng, Jason et al. (2017) Re-irradiation for recurrent glioma- the NCI experience in tumor control, OAR toxicity and proposal of a novel prognostic scoring system. Radiat Oncol 12:191
de Groot, John F; Piao, Yuji; Tran, Hai et al. (2011) Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept. Clin Cancer Res 17:4872-81
Steeg, Patricia S; Camphausen, Kevin A; Smith, Quentin R (2011) Brain metastases as preventive and therapeutic targets. Nat Rev Cancer 11:352-63
Stall, Bronwyn; Zach, Leor; Ning, Holly et al. (2010) Comparison of T2 and FLAIR imaging for target delineation in high grade gliomas. Radiat Oncol 5:5
Shabason, Jacob E; Camphausen, Kevin (2010) Cancer stem cells as a prognostic indicator for glioblastoma multiforme. Biomark Med 4:127-8
Shabason, Jacob E; Tofilon, Philip J; Camphausen, Kevin (2010) HDAC inhibitors in cancer care. Oncology (Williston Park) 24:180-5
Camphausen, Kevin (2009) Seminars in Radiation Oncology. Introduction. Semin Radiat Oncol 19:141
Kurshan, Naamit; Citrin, Deborah E; Camphausen, Kevin A (2009) Research highlights. Biomark Med 3:17-9
Russo, Andrea L; Jedlicka, Kimberly; Wernick, Meredith et al. (2009) Urine analysis and protein networking identify met as a marker of metastatic prostate cancer. Clin Cancer Res 15:4292-8

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