Metabolic Studies of Mouse Models of Obesity and Diabetes

Gavrilova, Oksana

Abstract

The following projects have been supported by Mouse Metabolism Core Laboratory in FY 2013 1. DK031131 Role of muscarinic acetylcholine receptors in glucose and energy homeostasis Principal Investigator: Jurgen Wess (LBC, NIDDK) 2. DK043313 Role of the Gnas Gene in Metabolic Regulation Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 3. DK043315 Role of Gs-alpha in central regulation of energy and glucose metabolism Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 4. DK043316 Role of Gs-alpha in regulation of adipose tissue growth and function Principal Investigator: Lee S. Weinstein (MDB, NIDDK) 5. DK025102 Erythropoietin receptor and glucose metabolism Principal Investigator: Constance T Noguchi (MCB, NIDDK) 6. DK075004 Identification of novel molecules and pathways that modulate adipogenesis Principal Investigator: Elisabetta Mueller (GDDB, NIDDK) 7. DK075003 Regulation of PPARgamma expression and adipogenesis by PTIP-associated factors Principal Investigator: Kai Ge (NRB, NIDDK) 8. DK075017 Epigenetic regulation of adipogenesis. Principal Investigator: Kai Ge (NRB, NIDDK) 9. DK031116 Development of P2Y receptor ligands Principal Investigator: Kenneth A Jacobson (MR, NIDDK) 10. DK060101 Targeted disruption the enzymes of O-GlcNAc cycling: animal models of disease Principal Investigator: John A Hanover (LCMB, NIDDK) 11. DK075040 Signaling pathways in control of growth and development. Principal Investigator: Alan Robert Kimmel (MMD, NIDDK) 12. DK075057 DEOB Physiology and Pharmacology of BRS-3 (Bombesin Receptor Subtype-3) Principal Investigator: Marc L. Reitman (DEOB, NIDDK) 13. DK075063 DEOB What can body temperature tell us about energy homeostasis? Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 14. DK075064 DEOB Role of brown adipose tissue (BAT) in energy balance Principal Investigator: Mark L. Reitman (DEOB, NIDDK) 15. DK061000 LGP Genetic Approaches to Understanding Organ Development and Function Principal Investigator: Lothar Hennighausen (LGP, NIDDK) 16. DK056018-06 (2012) Sphingolipid Biology and Regulation of Metabolism Principal Investigator: Richard L Proia (GDDB, NIDDK) 17. DK056014 Mouse Models of Novel Sphingolipid Biology and Disease Principal Investigator: Richard L Proia (GDDB, NIDDK) 18. DK054506 Vitamin C (ascorbic acid) Biochemistry and Molecular Biology Principal Investigator: Mark A Levine (DDB, NIDDK) 19. DK036150 Organization and regulation of the human insulin locus Principal Investigator: Gary Felsenfeld (LMB, NIDDK) 20. DK075035 Genes associated with endocrine tumorigenesis Principal Investigator: Sunita K Agarwal (MDB, NIDDK) 21. BC005708 Xenobiotic receptors Principal Investigator: Frank J Gonzalez (LM, NCI) 22. BC011197 Regulation and Function of WIP1 Phosphatase and its Role in Tumor Cells Principal Investigator: Ettore Appella (CI, NCI) 23. HD000641 Physiology, psychology, and genetics of obesity Principal Investigator: Jack Adam Yanovski (UGO, NICHD) 24. HD000642 Molecular Genetics of Adrenocortical Tumors And Related Disorders Principal Investigator: Constantine A Stratakis (PDEG, NICHD) 25. HD008898 Neuroendocrine Regulation of Metabolism and Neurocognition Principal Investigator: Joan C. Han (UMN, NICHD)

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Scientific Cores Intramural Research (ZIC)
• Project #: 1ZICDK070002-09
• Application #: 8741642
• Support Year: 9
• Fiscal Year: 2013
• Total Cost: $719,742

Institution

• Name: National Institute of Diabetes and Digestive and Kidney Diseases

Publications

Xiao, Cuiying; Piñol, Ramón A; Carlin, Jesse Lea et al. (2018) Corrigendum to ""Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism"" [Mol Metabol 6 (2017) 1540-1550]. Mol Metab 9:220

Jain, Shalini; Panyutin, Anna; Liu, Naili et al. (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab 315:E357-E366

Xu, Lingyan; Ma, Xinran; Verma, Narendra Kumar et al. (2018) Ablation of PPAR? in subcutaneous fat exacerbates age-associated obesity and metabolic decline. Aging Cell 17:

Podyma, Brandon; Sun, Hui; Wilson, Eric A et al. (2018) The stimulatory G protein Gs? is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism. J Biol Chem 293:10993-11005

Liu, Wenli; Aerbajinai, Wulin; Li, Hongzhen et al. (2018) Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet. Endocrinology 159:3235-3244

Zhuang, Lenan; Jang, Younghoon; Park, Young-Kwon et al. (2018) Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun 9:1796

Carlin, Jesse Lea; Jain, Shalini; Duroux, Romain et al. (2018) Activation of adenosine A2A or A2B receptors causes hypothermia in mice. Neuropharmacology 139:268-278

Chen, Min; Shrestha, Yogendra B; Podyma, Brandon et al. (2017) Gs? deficiency in the dorsomedial hypothalamus underlies obesity associated with Gs? mutations. J Clin Invest 127:500-510

Alexaki, Aikaterini; Clarke, Benjamin A; Gavrilova, Oksana et al. (2017) De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem 292:3929-3939

Park, Sung-Jun; Gavrilova, Oksana; Brown, Alexandra L et al. (2017) DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. Cell Metab 25:1135-1146.e7