Abstract

The Histopathology Core of the NEI, This consists of processing human and animal tissues from NEI researchers to research human diseases (mainly ocular tissues). Histology Core in charge to process the tissues for macroscopy, section it and stain slides for light and/or transmission electron microscopy. During FY15 (June 03 to September 30), the Histopathology Core received and processed approximately: EM 81(EM)specimens and yielded over 1640 EM image. Methacrylate and Paraffin 781 specimens 1062 provided slides Additionally, the laboratory processed case materials sent for ultrastructure, which produced electron microscopic images. About 95% of our effort is devoted to NEI duties but we also accept samples to process from another institutes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICEY000461-08
Application #
9155639
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Dong, Fei; Jin, Xueting; Boettler, Michelle A et al. (2018) A Mouse Model of Schnyder Corneal Dystrophy with the N100S Point Mutation. Sci Rep 8:10219
Wang, Herui; Shepard, Matthew J; Zhang, Chao et al. (2018) Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina. Cancer Res 78:1266-1274
Campos, Maria Mercedes; Abu-Asab, Mones S (2017) Loss of endothelial planar cell polarity and cellular clearance mechanisms in age-related macular degeneration. Ultrastruct Pathol 41:312-319
Chwiki, Sarah; Campos, Maria Mercedes; McLaughlin, Mary E et al. (2017) Adverse effects of antiretroviral therapy on liver hepatocytes and endothelium in HIV patients: An ultrastructural perspective. Ultrastruct Pathol 41:186-195
Hinshaw, Samuel J H; Ogbeifun, Osato; Wandu, Wambui S et al. (2016) Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration. Invest Ophthalmol Vis Sci 57:1441-7
Sun, Xun; Park, James H; Gumerson, Jessica et al. (2016) Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations. Proc Natl Acad Sci U S A 113:E2925-34
Ma, Wenxin; Wong, Wai T (2016) Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease. Adv Exp Med Biol 854:73-8
May-Simera, Helen L; Gumerson, Jessica D; Gao, Chun et al. (2016) Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina. Cell Rep 17:1399-1413
Wang, Yujuan; Hanus, Jakub W; Abu-Asab, Mones S et al. (2016) NLRP3 Upregulation in Retinal Pigment Epithelium in Age-Related Macular Degeneration. Int J Mol Sci 17:
Wang, Xu; Zhao, Lian; Zhang, Jun et al. (2016) Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. J Neurosci 36:2827-42

Showing the most recent 10 out of 139 publications