Abstract

The Biophysics Core Facility service to the NIH scientific community consists of four main categories: direct research support including instrument use, collaboration on research projects and scientific consultations, development and optimization of measurement methods, and user training. In the reporting period the total workload of the Biophysics Core Facility exceeded 2,000 user/hours. During this time, the Biophysics Core Facility users included principal investigators, staff scientists, postdocs and students from the following labs: NHLBI laboratories (by the PI last name): Ackerman, Hans; Alushin, Gregory; Balaban, Robert; Burg, Maurice; Chung, Jay; Ferre-DAmare, Adrian; Geller, Herbert; Hogg, Bobby; Korn, Edward; Larochelle, Andre; Lee, Jennifer; Levine, Rodney; Neuman, Keir; Peterkofsky, Alan; Remaley, Alan; Roll-Mecak, Antonina; Rusan, Nasser; Sellers, James; Swenson, Rolf; Taraska, Justin; Tjandra, Nico. Other NIH laboratories: Altan-Bonnet, Gregoire (NCI); Buchanan, Susan (NIDDK); Dyda, Frederick (NIDDK); Gottesman, Susan (NCI); Kim, Hee-Yong (NIAAA); Kimura, Shioko (NCI); Lenardo, Michael (NIAID); Neckers, Len (NCI); O'Connell Kevin (NIDDK); Ramamurthi, Kumaran (NCI); Roberts, David (NCI); Wickner, Sue (NCI); Wistow, Graeme (NEI); Yamada, Yoshi (NIDCR); Yamada, Yoshi (NIDCR).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Scientific Cores Intramural Research (ZIC)
Project #
1ZICHL000338-16
Application #
9362241
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Liu, Xiong; Billington, Neil; Shu, Shi et al. (2017) Effect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin II. Proc Natl Acad Sci U S A 114:E6516-E6525
O'Neil, Patrick K; Richardson, Lynn G L; Paila, Yamuna D et al. (2017) The POTRA domains of Toc75 exhibit chaperone-like function to facilitate import into chloroplasts. Proc Natl Acad Sci U S A 114:E4868-E4876
Hayoz, Sebastien; Tiwari, Purushottam B; Piszczek, Grzegorz et al. (2017) Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance. PLoS One 12:e0185359
Jung, Goeh; Alexander, Christopher J; Wu, Xufeng S et al. (2016) V-1 regulates capping protein activity in vivo. Proc Natl Acad Sci U S A 113:E6610-E6619
Liu, W; Li, H; Hong, S-H et al. (2016) Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice. Oncogene :
Paez-Segala, Maria G; Sun, Mei G; Shtengel, Gleb et al. (2015) Fixation-resistant photoactivatable fluorescent proteins for CLEM. Nat Methods 12:215-8, 4 p following 218
Zhao, Huaying; Piszczek, Grzegorz; Schuck, Peter (2015) SEDPHAT--a platform for global ITC analysis and global multi-method analysis of molecular interactions. Methods 76:137-148
Zhao, Huaying; Ghirlando, Rodolfo; Alfonso, Carlos et al. (2015) A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation. PLoS One 10:e0126420
Gruschus, James M; Jiang, Zhiping; Yap, Thai Leong et al. (2015) Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C. Biochem Biophys Res Commun 457:561-6
Rout, Ashok K; Strub, Marie-Paule; Piszczek, Grzegorz et al. (2014) Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy. J Biol Chem 289:35111-23

Showing the most recent 10 out of 36 publications