The NIDCD Core for Clinical Research and Care supported the following NIDCD projects: 1 Z01-DC-000016-16 NF-kappaB in the molecular pathogenesis and therapy of Neoplasms Affecting Human Communication 1 Z01 DC000031-15 Functional Neuroimaging Studies in Humans 1 Z01 DC000039-13 Identification of Genes Causing Syndromic And Nonsyndromic Hearing Impairment 1 Z01 DC000046-12 Genetic Studies of Human Communications Disorders 1 Z01 DC000057-11 Brain Imaging And Modeling 1 Z01 DC000060-09 Molecular Analysis Of Human Hereditary Deafness 1 Z01 DC000064-09 Clinical Analysis Of Disorders Of Hearing And Balance 1 Z01-DC-000073-2 Signal and Transcription Factor Network Interactions in Head and Neck Cancer 1 Z01-DC-000074-2 Genomics and Proteomics of Head and Neck Cancer The NIDCD protocols supported by the core include: T-DC-0005 Studies of Measures of Attention Oh93-DC-0016 - Nonsyndromic Hereditary Hearing Impairment Gene Mapping: India / Pakistan Protocol 92-DC-0178 - Functional Neuroimaging Studies of Speech Motor Control and Language Processing 97-DC-0057 - Non-parametric and parametric Linkage Studies of Stuttering 97-DC-0180 - Genetic Analysis of Human Hereditary Hearing Impairment 00-DC-0073- Identification of Hereditary Auditory Processing Defiicts 00-DC-0176 - Genetic Studies of Tune Deafness 01-DC-0099 - Evaluation for NIDCD Head and Neck Surgery Branch Clinical Research Protocols 01-C-0104 - A Phase I Study of Concomitant Therapy with Preoteasome Inhibitor PS-341 and Radiation in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. 01-DC-0228 - Clinical and Molecular Analysis of Hearing Impairment Associated with Enlarged Vestibular Aqueducts (EVA) 01-DC-0229- Genetic Analysis of Hereditary Disorders of Hearing and Balance 01-DC-0230 - Studies in the Deficits in the Sense of Taste 02-DC-0008 - Assessment of pre- and post-synaptic dopamine function in developmental stuttering using C-11 raclopride and PET 05-DC-0238 - Effects of Sleep Deprivation and Recovery Sleep on Speech, Language and Other Higher Cognitive Functions: A Combined EEG-fMRI Study 06-DC-0218 - Neural Modeling and Brain Imaging of Tinnitus 08-C-0071 - Phase I Study of Bortezmib and Cetuximab without or with Cisplatin with Radiation therapy for Patients with Advanced Head and Neck Cancer The NIDCD Core for Clinical Research and Care in FY08 supported over 5,000 outpatient clinic evaluations, a 50% increase over the prior year. Core otolaryngologists performed over 100 major surgical cases. Staff mentored medical students during senior clinical clerkships.Collaborative studies resulted in contributions to several manuscripts and book chapters. Citrin D, Mansuetti J, Likhacheva A, Sciuto L, Albert PS, Rudy SF, Cooley-Zgela T, Cotrim A, Solomon B, Colevas AD, Russo A, Morris JC, Herscher L, Smith S, Van Waes C. Long-term outcomes and toxicity of concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer, Int J Rad Oncol Biol Phys, 2009;74:1040-6. Savage SA, Dokal I, Armanios M, Aubert G, Cowen EW, Domingo DL, Giri N, Orchard PJ, Tolar J, Tsilou E, Van Waes C, Wong JMY, Young NS, Alter BP. Dyskeratosis congenita: The first NIH clinical research workshop. Ped Blood &Cancer, 2009;2009;53:520-3 Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CR, Restifo NP, Schwarz SL, Cogdil AP, Bishop RJ, Kim HJ, Brewer CC, Rudy SF, Van Waes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA. Gene therapy with human and mouse T cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood, 2009, in press 2009;114:535-46. Estrada DT, Van Waes C, Moni J, Conley BA. Head and Neck Cancer. In, Abraham J, Gulley JL, Allegra CJ, Ed. The Bethesda Handbook of Clinical Oncology, Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia, 2010, 3-34

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2009
Total Cost
$1,070,383
Indirect Cost
Name
National Institute on Deafness and Other Communication Disorders
Department
Type
DUNS #
City
State
Country
Zip Code
Wingfield, L R; Liu, J; Hu, M et al. (2018) Nine patients with chronic granulomatous disease having selective neck dissection for severe cervical lymphadenitis. Clin Otolaryngol 43:335-340
Rose, Jane; Muskett, Julie A; King, Kelly A et al. (2017) Hearing loss associated with enlarged vestibular aqueduct and zero or one mutant allele of SLC26A4. Laryngoscope 127:E238-E243
Lindsey, Spencer; Brewer, Carmen; Stakhovskaya, Olga et al. (2017) Auditory and otologic profile of Alström syndrome: Comprehensive single center data on 38 patients. Am J Med Genet A 173:2210-2218
Ory, Daniel S; Ottinger, Elizabeth A; Farhat, Nicole Yanjanin et al. (2017) Intrathecal 2-hydroxypropyl-?-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1-2 trial. Lancet 390:1758-1768
Xiao, R; Van Waes, C; Schmitt, N C (2017) Putting T cells to work-outsourcing neoantigen detection in head and neck cancers? Oral Dis 23:820-821
Davis, Ruth J; Moore, Ellen C; Clavijo, Paul E et al. (2017) Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3K?/?. Cancer Res 77:2607-2619
Naz, Sadaf; Imtiaz, Ayesha; Mujtaba, Ghulam et al. (2017) Genetic causes of moderate to severe hearing loss point to modifiers. Clin Genet 91:589-598
Brendal, Megan A; King, Kelly A; Zalewski, Christopher K et al. (2017) Auditory Phenotype of Smith-Magenis Syndrome. J Speech Lang Hear Res 60:1076-1087
Kukke, Sahana N; Brewer, Carmen C; Zalewski, Christopher et al. (2017) Hearing Safety From Single- and Double-Pulse Transcranial Magnetic Stimulation in Children and Young Adults. J Clin Neurophysiol 34:340-347
Elghouche, Alhasan; Shokri, Tom; Qin, Yewen et al. (2016) Unilateral Cervical Polyneuropathies following Concurrent Bortezomib, Cetuximab, and Radiotherapy for Head and Neck Cancer. Case Rep Otolaryngol 2016:2313714

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