Credentialed NIDDK clinical staff members have relevant expertise necessary to support patient care needs of human subjects involved in clinical research conducted by all institutes and centers in the intramural research program. Consultative interactions provided by NIDDK clinicians with expertise in the fields of diabetes, endocrinology, metabolism, gastroenterology, hepatology, nephrology and hematology are required for delivery of specialized medical services to patients throughout the Clinical Research Center at NIH. Beyond patient support services, these consultative interactions lead to collaborative clinical investigations to advance the study of natural history of disease, new approaches to diagnosis and treatment, as well as advancing the understanding of disease pathogenesis and pathophysiology. Clinical services include: 1. Blood Glucose Management Service involves comprehensive management of patients with insulin deficient or insulin resistant diabetes mellitus. 2. Consultation services in endocrinology, gastroenterology, hepatology, nephrology, cystic fibrosis and hematology. 3. Gastrointestinal endoscopy, including biopsies and therapeutic procedures 4. Liver biopsies and liver fibroscanning 5. Renal biopsies, hemodialysis, continuous veno-venous hemofiltration, specialized research renal function tests 6. Biorepository 7. Biostatistical support Examples of recently completed and ongoing collaborative clinical research projects emerging from consultation activities include: 1. Endocrine, gastrointestinal, liver and kidney complications of immunotherapy of metastatic melanoma, stem cell transplantation, chemotherapy and novel biologic anti-tumor agents (NCI, NHLBI); 2. Gastrointestinal complications of graft versus host disease (NHLBI, NCI, NIAID); 3. Liver complications of chronic granulomatous disease (NIAID), Hermansky-Pudlak syndrome (NHGRI) and cystinosis(NHGRI); 4. Natural history and management of kidney and liver complications of sickle cell anemia (NHLBI); 5. Renal complications of HIV disease and HIV drug therapies (NIAID); 6. Kidney manifestations and effects of recombinant enzyme treatment of Fabry disease (NINDS); 7. Membranous nephropathy in patients with non-myeloablative stem cell transplants (NHLBI); 8. Renal vasculitis in Wiskott-Aldrich syndrome (NHGRI); 9. Endothelial injury and thrombotic microangiopathy in stem cell transplants (NHLBI, NCI, NIAID)

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2011
Total Cost
$1,216,570
Indirect Cost
City
State
Country
Zip Code
Brown, Rebecca J; Araujo-Vilar, David; Cheung, Pik To et al. (2016) The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline. J Clin Endocrinol Metab 101:4500-4511
Sylvetsky, Allison C; Brown, Rebecca J; Blau, Jenny E et al. (2016) Hormonal responses to non-nutritive sweeteners in water and diet soda. Nutr Metab (Lond) 13:71
Zhou, Hua; Hasni, Sarfaraz A; Perez, Paola et al. (2013) miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1. J Am Soc Nephrol 24:1073-87
Alvarez-Downing, Melissa M; Kamal, Natasha; Inchauste, Suzanne M et al. (2013) The role of surgery in the management of patients with refractory chronic granulomatous disease colitis. Dis Colon Rectum 56:609-14
Gormley, Nicole J; Bronstein, Alvin C; Rasimas, Joseph J et al. (2012) The rising incidence of intentional ingestion of ethanol-containing hand sanitizers. Crit Care Med 40:290-4
Maguire, Marcy; Lungu, Andrea; Gorden, Phillip et al. (2012) Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction. Obstet Gynecol 119:452-5
Fan, Xiying; Upadhyaya, Bhaskar; Wu, Liming et al. (2012) CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome. Clin Immunol 143:152-61
Monti, Daniel A; Mitchell, Edith; Bazzan, Anthony J et al. (2012) Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLoS One 7:e29794
Castillo, Darleen C; Ramsey, Natalie Lm; Yu, Sophia Sk et al. (2012) Inconsistent Access to Food and Cardiometabolic Disease: The Effect of Food Insecurity. Curr Cardiovasc Risk Rep 6:245-250
Lungu, Andreea O; Zadeh, Elika Safar; Goodling, Anne et al. (2012) Insulin resistance is a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome. J Clin Endocrinol Metab 97:563-7

Showing the most recent 10 out of 17 publications