A number of medical retinal protocols have been conducted at the NEI clinical center. Many are phase 1 studies while others are studies in the screening and evaluation and treatment protocol. These provide patients for screening for trials and epidemiologic studies conducted by the Division of Epidemiology and Clinical Applications. These include the followup of Age-Related Eye Disease Study (AREDS2) and AREDS2 follow-up, lucentis or avastin (anti-VEGF therapy) for treatment of diabetic macular edema, while lucentis for a study of high speed indocyanine green angiography for age-related macular degeneration, treatment with microglial inhibitors for diabetic retinopathy and retinovascular occlusions, treatments for central serous retinopathy, and genetic studies of age-related macular degeneration. We have also had a biobank protocol where we would collect DNA and blood for a number of retinovascular diseases. We are also beginning a collaboration with the NINDS on evaluating the fundus of patients with Alzheimer's disease and with NINDS on HIV ocular findings in those with HIV associated neurodegeneration.

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National Eye Institute (NEI)
Clinical Training Intramural Research (ZIE)
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Nicholson, Benjamin P; Nigam, Divya; Toy, Brian et al. (2015) Effect of ranibizumab on high-speed indocyanine green angiography and minimum intensity projection optical coherence tomography findings in neovascular age-related macular degeneration. Retina 35:58-68
Chew, Emily Y; Klein, Michael L; Clemons, Traci E et al. (2014) No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38. Ophthalmology 121:2173-80
Age-Related Eye Disease Study 2 Research Group; Huynh, Nancy; Nicholson, Benjamin P et al. (2014) Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5. Ophthalmology 121:1229-36
Aronow, Mary E; Chew, Emily Y (2014) Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. Curr Opin Ophthalmol 25:186-90
Chu, Xi K; Meyerle, Catherine B; Liang, Xiaoling et al. (2014) In-depth analyses unveil the association and possible functional involvement of novel RAD51B polymorphisms in age-related macular degeneration. Age (Dordr) 36:9627
Pacak, Karel; Chew, Emily Y; Pappo, Alberto S et al. (2014) Ocular manifestations of hypoxia-inducible factor-2? paraganglioma-somatostatinoma-polycythemia syndrome. Ophthalmology 121:2291-3
Age-Related Eye Disease Study 2 (AREDS2) Research Group; Chew, Emily Y; SanGiovanni, John Paul et al. (2013) Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4. JAMA Ophthalmol 131:843-50
Ratnapriya, R; Chew, E Y (2013) Age-related macular degeneration-clinical review and genetics update. Clin Genet 84:160-6
Dalal, Monica; Jacobs-El, Naima; Nicholson, Benjamin et al. (2013) Subconjunctival Palomid 529 in the treatment of neovascular age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 251:2705-9
Domalpally, Amitha; Danis, Ronald P; Chew, Emily Y et al. (2013) Evaluation of optimized digital fundus reflex photographs for lens opacities in the age-related eye disease study 2: AREDS2 report 7. Invest Ophthalmol Vis Sci 54:5989-94

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