The speciality field of laboratory animal medicine and care covers a diverse array of responsibilities. The Rocky Mountain Veterinary Branch (RMVB) staff may encounter unusual clinical cases and emerging murine infectious diseases during their normal work duties that are conducive to study. The construction and management of facilities for human emerging diseases and potential bioterrorism agent research also results in unique experiences. Investigation of these observations and experiences contributes to advancing the body of knowledge within the laboratory animal field. The diligent RMVB staff provide the support necessary for DIR investigators to conduct cutting edge research.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2012
Total Cost
$8,385,737
Indirect Cost
City
State
Country
Zip Code
Haddock, Elaine; Feldmann, Friederike; Hawman, David W et al. (2018) A cynomolgus macaque model for Crimean-Congo haemorrhagic fever. Nat Microbiol 3:556-562
Lavender, Kerry J; Williamson, Brandi N; Saturday, Greg et al. (2018) Pathogenicity of Ebola and Marburg Viruses Is Associated With Differential Activation of the Myeloid Compartment in Humanized Triple Knockout-Bone Marrow, Liver, and Thymus Mice. J Infect Dis :
Hawman, David W; Haddock, Elaine; Meade-White, Kimberly et al. (2018) Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice. Antiviral Res 157:18-26
Marzi, Andrea; Emanuel, Jackson; Callison, Julie et al. (2018) Lethal Zika Virus Disease Models in Young and Older Interferon ?/? Receptor Knock Out Mice. Front Cell Infect Microbiol 8:117
de Wit, Emmie; Siegers, Jurre Y; Cronin, Jacqueline M et al. (2018) 1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets. J Infect Dis 217:1237-1246
Zivcec, Marko; Safronetz, David; Scott, Dana P et al. (2018) Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge. PLoS Negl Trop Dis 12:e0006628
Rosenke, Kyle; Bounds, Callie E; Hanley, Patrick W et al. (2018) Human Polyclonal Antibodies Produced by Transchromosomal Cattle Provide Partial Protection Against Lethal Zaire Ebolavirus Challenge in Rhesus Macaques. J Infect Dis :
Rosenke, Kyle; Feldmann, Heinz; Westover, Jonna B et al. (2018) Use of Favipiravir to Treat Lassa Virus Infection in Macaques. Emerg Infect Dis 24:1696-1699
Marzi, Andrea; Chadinah, Spencer; Haddock, Elaine et al. (2018) Recently Identified Mutations in the Ebola Virus-Makona Genome Do Not Alter Pathogenicity in Animal Models. Cell Rep 23:1806-1816
Prescott, Joseph; Falzarano, Darryl; de Wit, Emmie et al. (2018) Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques. Front Immunol 9:205

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