Prof. Cecilia Clementi of Rice University is supported by this CAREER award to study the mechanism and dynamics of the protein folding process. New coarse-grained models are being developed which greatly reduce the extent of the phase space that needs to be considered. Both inverse Monte carlo and dissipative particle dynamics methods are used to seek effective potentials and a unique algorithm developed for robotics applications is used for motion-planning on the protein landscape.

The broader impacts of this research are in the biological sciences. Along with the research itself, Prof. Clementi is involved with the development of a new course in computational molecular biology and an outreach program involving presentations to local schools.

This project is supported by the Theoretical and Computational Chemistry program in the Division of Chemistry and the Molecular Biophysics program in the Division of Molecular and Cellular Biology.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Type
Standard Grant (Standard)
Application #
0349303
Program Officer
Evelyn M. Goldfield
Project Start
Project End
Budget Start
2004-04-01
Budget End
2010-09-30
Support Year
Fiscal Year
2003
Total Cost
$500,000
Indirect Cost
Name
Rice University
Department
Type
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77005