This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will continue work on the development of methods for the regio- and chemoselective assembly of carbo- and heterocyclic organic structures using the [2+2+2] cyclotrimerization reaction as a key step. Despite innovative research development over the last decades, transition-metal catalyzed cyclotrimerization reactions still suffer from inherent selectivity and reactivity issues. This research will address these fundamental problems through the synergistic combination of solid-supported chemistry, linker design, catalyst development, and the utilization of microwave irradiation. The unifying cyclotrimerization conditions discovered through this work will be applied to the synthesis of different benzene- and pyridine-containing natural products.

With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Alexander Deiters in the Department of Chemistry at North Carolina State University. Professor Deiters' research efforts revolve around the development of new methods for the rapid assembly of carbo- and hetero-cyclic structures using cycloaddition reactions. Such chemistry will contribute efficient synthetic methodologies, which will have an impact in the pharmaceutical and agricultural industries. The developed methodology will also enable the assembly of organic molecules in a more energy efficient way than existing methodologies.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Type
Standard Grant (Standard)
Application #
0846756
Program Officer
Tingyu Li
Project Start
Project End
Budget Start
2009-07-01
Budget End
2014-06-30
Support Year
Fiscal Year
2008
Total Cost
$500,000
Indirect Cost
Name
North Carolina State University Raleigh
Department
Type
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695