The research of Dr. Donald Deardorff is supported by the Synthetic Organic Chemistry Program. Deardorff is an associate professor of chemistry at Occidental College. He is studying new methods for the stereocontrolled preparation of carbocyclic analogues of purine nucleosides, molecules having important applications in the development of new medicines. In particular, new approaches using organopalladium chemistry will be examined. The goal of the project is to develop novel synthetic strategies which permit facile, stereocontrolled access to both saturated and unsaturated carbocyclic analogues of purine nucleosides. Strategies to be used make reiterative use of (pi-allyl)palladium chemistry. Natural product targets used to showcase developed synthetic technologies include neplanocin and aristeromycin. The introduction of chirality into the synthesis will be accomplished by employing enzymatic reactions to prepare key starting materials.

Agency
National Science Foundation (NSF)
Institute
Division of Chemistry (CHE)
Application #
8908212
Program Officer
John S. Showell
Project Start
Project End
Budget Start
1989-07-01
Budget End
1992-12-31
Support Year
Fiscal Year
1989
Total Cost
$114,122
Indirect Cost
Name
Occidental College
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90041