The simulation of fluid flow in bones has received considerable attention in the field of biomechanics. Limited studies have been conducted up to date to investigate the deformation and fluid pressure of bone under well controlled conditions. A series of experimental studies is proposed to investigate the response of bone specimens under monotonic followed by cyclic loadings. In the experiment, the bone specimen is confined in a rubber membrane using an all-around pressure enclosed in a newly developed device. The induced deformation and fluid pressure are measured under drained and undrained conditions, respectively. The development of plastic strains and accumulated fluid pressure under cyclic loading will be revealed for different stress amplitudes and frequencies. The study is undertaken as a cross-disciplinary and cross-institutional research between applied mechanics (geomechanics) and medical science. The understanding of mechanisms of load-induced fluid flow would lead to a better interpretation of mechanosensory function in bones that has significant clinical implications.
