9219043 Frank The understanding of biological function requires a multi- level approach to the study of structure and a mapping of the enormous complexity in an accessible way. To this end, tools must be developed, along with an appropriate computational infrastructure, that are able to visualized, match, an d combine three-dimensional data from different sources (x-ray, electron microscopy (EM) and light microscopy (LM)). Current computational tools are unable to realized opportunities clearly opened up by current computer technology. This award will support the multidisciplinary group of investigators to upgrade the computational environment in such a way that (i) it is suitable for the interpretation of 3D data from various experimental sources; (ii) it facilitates correlative 3D studies; and (ii) it becomes accessible to the biologist. Among the systems studies are the ribosome and its interaction with RNA; the mechanism of mitosis; the mechanism of excitation-contraction coupling in the muscle cell and the interactions between hippocampal pyramidal cells. The award will support the purchase of a parallel computer, a system of workstations, and the development of corresponding software. The award is being supported by the Computational Biology Activities and the Instrumentation and Instrument Development programs. ***

Agency
National Science Foundation (NSF)
Institute
Division of Biological Infrastructure (DBI)
Application #
9219043
Program Officer
THOMAS QUARLES
Project Start
Project End
Budget Start
1993-08-15
Budget End
1997-01-31
Support Year
Fiscal Year
1992
Total Cost
$730,724
Indirect Cost
Name
Health Research Incorporated/New York State Department of Health
Department
Type
DUNS #
City
Menands
State
NY
Country
United States
Zip Code
12204