Amphibian populations around the world are experiencing declines and mass mortalities at an unprecedented rate. The fungal disease chytridiomycosis is a primary cause of this epidemic, and differential susceptibility among species occurring in similar environments suggests that genetics may determine how individuals respond to infection. Zamudio and Lips will combine field and laboratory studies to test whether variability in immunity genes of the major histocompatibility complex (MHC) confer differential survivorship to this emerging infectious disease, and how the disease itself alters the genetic and demographic composition of populations following an outbreak. The proposal focuses on frog populations in Central America where chytridiomycosis lethality is prevalent; however, their findings will be applicable to amphibian populations worldwide.

This project will provide a better understanding of how emerging diseases shape adaptive molecular evolution, and how variability in immunity genes contribute to the response to novel disease threats. This research will quantify the molecular effects of this disease in ?real-time?, in addition to the genetic determinants of survivorship, resulting in useful epidemiological predictions for other populations or species that have yet to be exposed to the disease.

Agency
National Science Foundation (NSF)
Institute
Division of Environmental Biology (DEB)
Type
Standard Grant (Standard)
Application #
0815288
Program Officer
Nancy J. Huntly
Project Start
Project End
Budget Start
2008-10-01
Budget End
2009-03-31
Support Year
Fiscal Year
2008
Total Cost
$100,000
Indirect Cost
Name
Southern Illinois University at Carbondale
Department
Type
DUNS #
City
Carbondale
State
IL
Country
United States
Zip Code
62901