Acetylcholine is the most common neurotransmitter found in specialized vesicles of nerve cells. The regulation of the amount of acetylcholine is critical since this neurochemical is important in nerve cell communication. The goal of this research is to study the chemical nature of the molecules which transport acetylcholine into storage vesicles. Biochemical and immunochemical techniques will be used to purify and sequence peptides associated with the binding sites. The investigator has developed and synthesized specialized molecules which can react with the transport molecule by labeling the molecule for further chemical analysis. In addition to examining the chemical nature of the transport molecule, this study will provide more information on other functions in which the acetylcholine transporter complex might perform in the cholinergic nerve terminal.

Agency
National Science Foundation (NSF)
Institute
Division of Integrative Organismal Systems (IOS)
Application #
9012227
Program Officer
Project Start
Project End
Budget Start
1990-09-01
Budget End
1994-08-31
Support Year
Fiscal Year
1990
Total Cost
$85,790
Indirect Cost
Name
University of California Santa Barbara
Department
Type
DUNS #
City
Santa Barbara
State
CA
Country
United States
Zip Code
93106