The basic plan of this project is to assemble a complete set of thermodynamic and structural data for a well defined set of peptides in order to explore specific questions concerning the nature of protein/bilayer interactions. This project is expected to lead to a refined view of such interactions and to provide information about hydrophobicity scales and their application in the assessment of membrane protein structure. The generally accepted image of membranes is that of a quasi two-dimensional solution of hydrophobic protein "solutes" partitioned into a lipid bilayer "solvent". It is important to develop a quantitative understanding of the bilayer as a solvent for hydrophobic molecules with the goal of describing not only interactions of hydrophobic peptides with bilayers but eventually the interactions of protein with membranes.***//

Agency
National Science Foundation (NSF)
Institute
Division of Molecular and Cellular Biosciences (MCB)
Application #
8807431
Program Officer
Arthur Kowalsky
Project Start
Project End
Budget Start
1988-08-01
Budget End
1992-01-31
Support Year
Fiscal Year
1988
Total Cost
$298,000
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
City
Irvine
State
CA
Country
United States
Zip Code
92697