The problem I intend to address is the function of sleep, a biological puzzle that is still unsolved. Specifically, Iintend to test a comprehensive, novel hypothesis about what sleep is for, called the synaptic homeostasishypothesis (Tononi and Cirelli, Brain Res Bull 2003, Sleep Medicine Rev., 2005). The hypothesis accounts formany facts about sleep and its regulation, from behavioral and phylogenetic evidence to electrophysiological andmolecular observations, and has fundamental implications for health and disease. The hypothesis makes intriguingpredictions that are relevant for both basic and clinical neuroscience, and I propose to test such predictions usingseveral complementary approaches. If the hypothesis survives the tests, we may have for the first time a solidscientific explanation of why we need to sleep.Understanding the function of sleep is obviously important both scientifically and from the perspective ofhuman health. Sleep is a pervasive, universal, and fundamental behavior: It occupies a third of our life, and aneven larger proportion in infants; it is present in every animal species where it has been studied, from fruit flies tohumans; it is tightly regulated, as indicated by the irresistible mounting of sleep pressure after prolongedwakefulness; and even partial deprivation of sleep has serious consequences on cognition, mood, and health.While all available evidence indicates that sleep is of the brain, by the brain, and for the brain, the function ofsleep remains unknown despite decades of intensive research. No comprehensive theory had been advanced sofar, which is why the synaptic homeostasis hypothesis, if corroborated, may constitute a much neededbreakthrough.In fact, the lack of understanding of why we need to sleep is problematic not only from a scientific viewpoint,but also because of its vast implications for public health. Millions of people complain of sleep problems, frominsomnia to excessive daytime sleepiness, from chronic fatigue to irritability associated with unsatisfactory sleep.Sleep problems are an important aspect of several psychiatric disorders, notably mood disorders and anxietydisorders. Finally, sleep deprivation has high social costs, from driving and work-related accidents to chronicallypoor performance. A large segment of the population is therefore treated routinely with drugs aimed at improvingsleep, or at maintaining wakefulness in the face of sleep pressure. However, such treatments are hampered by ourignorance concerning the functions of sleep. Which sleep disturbances should be taken seriously because theyreflect a functional impairment and which, if any, do not interfere significantly with the functions carried out bysleep? Which abnormalities of sleep are likely to have neurobiological consequences that can lead to psychiatricdisorders such as depression? And finally, what aspect of sleep should be enhanced by pharmacological orbehavioral treatments, and what indices should we consider to determine their effectiveness?

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
NIH Director’s Pioneer Award (NDPA) (DP1)
Project #
5DP1OD000579-04
Application #
7485011
Study Section
Special Emphasis Panel (ZGM1-NDPA-G (P3))
Program Officer
Vicentic, Aleksandra
Project Start
2005-09-30
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
4
Fiscal Year
2008
Total Cost
$710,404
Indirect Cost
Name
University of Wisconsin Madison
Department
Psychiatry
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Bellesi, Michele; de Vivo, Luisa; Koebe, Samuel et al. (2018) Sleep and Wake Affect Glycogen Content and Turnover at Perisynaptic Astrocytic Processes. Front Cell Neurosci 12:308
de Vivo, Luisa; Bellesi, Michele; Marshall, William et al. (2017) Ultrastructural evidence for synaptic scaling across the wake/sleep cycle. Science 355:507-510
Vyazovskiy, Vladyslav V; Olcese, Umberto; Cirelli, Chiara et al. (2013) Prolonged wakefulness alters neuronal responsiveness to local electrical stimulation of the neocortex in awake rats.. J Sleep Res 22:239-50
Dash, Michael B; Bellesi, Michele; Tononi, Giulio et al. (2013) Sleep/wake dependent changes in cortical glucose concentrations. J Neurochem 124:79-89
Huber, Reto; Maki, Hanna; Rosanova, Mario et al. (2013) Human cortical excitability increases with time awake. Cereb Cortex 23:332-8
Balduzzi, David; Tononi, Giulio (2013) What can neurons do for their brain? Communicate selectivity with bursts. Theory Biosci 132:27-39
Nelson, Aaron B; Faraguna, Ugo; Zoltan, Jeffrey T et al. (2013) Sleep patterns and homeostatic mechanisms in adolescent mice. Brain Sci 3:318-43
Dash, Michael B; Tononi, Giulio; Cirelli, Chiara (2012) Extracellular levels of lactate, but not oxygen, reflect sleep homeostasis in the rat cerebral cortex. Sleep 35:909-19
Boly, Mélanie; Moran, Rosalyn; Murphy, Michael et al. (2012) Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness. J Neurosci 32:7082-90
Sanders, Robert D; Tononi, Giulio; Laureys, Steven et al. (2012) Unresponsiveness ? unconsciousness. Anesthesiology 116:946-59

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