Adjuvant arthritis (AA) is inducible in Lewis rats by injection of heat-killed M. tuberculosis and it serves as an excellent model for human rheumatoid arthritis (RA). The 65 kD mycobacterial heat-shock protein (Bhsp65) is the focus of the T-cell responses of arthritic Lewis rats. T cells specific for the determinant (epitope) region 180-188/177-191 of Bhsp65 have been shown to be pathogenic in nature, whereas those primed by the Bhsp65 carboxy-terminal determinants (BCTD) are disease-regulating in nature. We hypothesize that the protective/beneficial effect of Celastrus orbiculatus (Celastrus) against arthritis (AA) involves differential modulation of the balance between T cell responses to the pathogenic and/or regulatory determinants of Bhsp65. This could be achieved by the action of Celastrus either on the function of the antigen presenting cells (APC) or on cytokine secretion (immune deviation from Thl to Th2, or TGF-beta secretion) by the Bhsp65-specific T cells, or both. We plan to test this proposition in our study. The results of this study would help in establishing a reliable scientific basis for use of Celastrus in autoimmune arthritis, and in developing better therapeutic approaches for patients with RA.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
International Research Fellowships (FIC) (F05)
Project #
5F05AT002013-04
Application #
7176829
Study Section
Special Emphasis Panel (ZAT1-CP (08))
Program Officer
Hayes, Deborah
Project Start
2004-03-01
Project End
2007-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
4
Fiscal Year
2006
Total Cost
$32,000
Indirect Cost
Name
Southern Medical University
Department
Type
DUNS #
529498615
City
Guangzhou
State
Country
China
Zip Code
51051-5
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