Abstract

Adjuvant arthritis (AA) is inducible in Lewis rats by injection of heat-killed M. tuberculosis and it serves as an excellent model for human rheumatoid arthritis (RA). The 65 kD mycobacterial heat-shock protein (Bhsp65) is the focus of the T-cell responses of arthritic Lewis rats. T cells specific for the determinant (epitope) region 180-188/177-191 of Bhsp65 have been shown to be pathogenic in nature, whereas those primed by the Bhsp65 carboxy-terminal determinants (BCTD) are disease-regulating in nature. We hypothesize that the protective/beneficial effect of Celastrus orbiculatus (Celastrus) against arthritis (AA) involves differential modulation of the balance between T cell responses to the pathogenic and/or regulatory determinants of Bhsp65. This could be achieved by the action of Celastrus either on the function of the antigen presenting cells (APC) or on cytokine secretion (immune deviation from Thl to Th2, or TGF-beta secretion) by the Bhsp65-specific T cells, or both. We plan to test this proposition in our study. The results of this study would help in establishing a reliable scientific basis for use of Celastrus in autoimmune arthritis, and in developing better therapeutic approaches for patients with RA.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
International Research Fellowships (FIC) (F05)
Project #
7F05AT002013-03
Application #
7022320
Study Section
Special Emphasis Panel (ZAT1-CP (08))
Program Officer
Pearson, Nancy
Project Start
2004-03-01
Project End
2007-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
3
Fiscal Year
2005
Total Cost
$88
Indirect Cost

  Institution

Name
Southern Medical University
Department
Type
DUNS #
529498615
City
Guangzhou
State
Country
China
Zip Code
51051-5

  Publications

García-Caballero, Cristina; Lieppman, Burke; Arranz-Romera, Alicia et al. (2018) Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF/melatonin in rhodopsin knockout mice. Mol Vis 24:733-745
García-Posadas, Laura; Hodges, Robin R; Diebold, Yolanda et al. (2018) Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators. Sci Rep 8:12162
Sawatzky, Richard; Laforest, Esther; Schick-Makaroff, Kara et al. (2017) Design and introduction of a quality of life assessment and practice support system: perspectives from palliative care settings. J Patient Rep Outcomes 2:36
Serrano-Sánchez, F; Gharsallah, M; Nemes, N M et al. (2017) Enhanced figure of merit in nanostructured (Bi,Sb)2Te3 with optimized composition, prepared by a straightforward arc-melting procedure. Sci Rep 7:6277
Al-Alshaikh, Monirah A; Abuelizz, Hatem A; El-Emam, Ali A et al. (2016) Crystal structure of 3-{[4-(2-meth-oxy-phen-yl)piperazin-1-yl]meth-yl}-5-(thio-phen-2-yl)-1,3,4-oxa-diazole-2(3H)-thione. Acta Crystallogr E Crystallogr Commun 72:269-72
Larrea, Edurne S; Mesa, José Luis; Legarra, Estibaliz et al. (2016) Crystal structure of K0.75[Fe(II) 3.75Fe(III) 1.25(HPO3)6]·0.5H2O, an open-framework iron phosphite with mixed-valent Fe(II)/Fe(III) ions. Acta Crystallogr E Crystallogr Commun 72:63-5
Fernández, Laura; Ilyn, Maxim; Magaña, Ana et al. (2016) Growth of Co Nanomagnet Arrays with Enhanced Magnetic Anisotropy. Adv Sci (Weinh) 3:1600187
Ferk, Gregor; Krajnc, Peter; Hamler, Anton et al. (2015) Monolithic Magneto-Optical Nanocomposites of Barium Hexaferrite Platelets in PMMA. Sci Rep 5:11395
Pérez-Aguirre, Rubén; Pérez-Yáñez, Sonia; Beobide, Garikoitz et al. (2015) The crystal structure of a new polymorph of hexa-aqua-nickel(II) bis-(6-oxo-1,6-di-hydro-pyridine-3-carboxyl-ate). Acta Crystallogr E Crystallogr Commun 71:m238-9
Bai, Shu-Tong; Chen, Pei-Hong; Chen, Yu-Yao et al. (2014) Ethyl Acetate Extract from Celastrus aculeatus Merr. Suppresses Synovial Inflammation in Adjuvant Arthritis Rats through Apoptosis Induction of CD4(+)CD25(+)FOXP3(+) T Cells. Evid Based Complement Alternat Med 2014:460136

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