This application is to provide predoctoral fellowship support for training in the analytical chemistry, biochemistry, and pharmacology of the dopaminergic transporter. The research will focus on the outward functioning the dopamine transporter in striatal and nucleus accumbens tissues from the rat in vitro. The transporter kinetics will be measured by rotating disk electrode voltammetry. The goals are to define the multisubstrate mechanism of the outward functioning dopamine transporter, determine how it is influenced by direct application of drugs of abuse (cocaine and amphetamine), and investigate how withdrawal from repeated treatments with cocaine alters its outward function.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31DA005762-02
Application #
2517894
Study Section
Human Development Research Subcommittee (NIDA)
Project Start
1997-08-16
Project End
Budget Start
1997-08-16
Budget End
1998-08-15
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Washington State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164