Abnormalities of cellular or tissue heterogeneity are thought to provide a mechanism for many forms of human arrhythmias. The objective of this project is to develop technologies that will correlate the structural and functional relationships of cardiac tissue morphology and conduction heterogeneities. This project will provide an enhancement to viewing the conduction of action potentials within cardiac tissue in three dimensions. By coupling functional imaging with structural imaging, three dimensional structural imaging and depth information of the action potentials can be acquired simultaneously. With this new system, we can test the hypothesis if there is a structural basis for the heterogeneity of action potential velocities and morphology in the AV node. Isolated AV node preparations from New Zealand White Rabbits will be used as a model in this project. Other models of cellular or tissue heterogeneity can be imaged with this system to correlate the structure-function relationship in substrates of arrhythmias. ? ? ?
| Wang, Hui; Kang, Wei; Carrigan, Thomas et al. (2011) In vivo intracardiac optical coherence tomography imaging through percutaneous access: toward image-guided radio-frequency ablation. J Biomed Opt 16:110505 |
| Fleming, Christine P; Wang, Hui; Quan, Kara J et al. (2010) Real-time monitoring of cardiac radio-frequency ablation lesion formation using an optical coherence tomography forward-imaging catheter. J Biomed Opt 15:030516 |
| Fleming, Christine P; Quan, Kara J; Wang, Hui et al. (2010) In vitro characterization of cardiac radiofrequency ablation lesions using optical coherence tomography. Opt Express 18:3079-92 |
| Fleming, Christine P; Quan, Kara J; Rollins, Andrew M (2010) Toward guidance of epicardial cardiac radiofrequency ablation therapy using optical coherence tomography. J Biomed Opt 15:041510 |
| Fleming, Christine P; Ripplinger, Crystal M; Webb, Bryan et al. (2008) Quantification of cardiac fiber orientation using optical coherence tomography. J Biomed Opt 13:030505 |
