Abstract

This study proposes to explore the role of voltage activated Ca2+ channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discern the relative roles of the various high voltage activated Ca2+ channels in the Ca2+-tail current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca2+ channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
1F31NS045437-01
Application #
6585247
Study Section
Special Emphasis Panel (ZRG1-F03B (21))
Program Officer
Talley, Edmund M
Project Start
2002-12-06
Project End
2005-12-05
Budget Start
2002-12-06
Budget End
2003-12-05
Support Year
1
Fiscal Year
2003
Total Cost
$41,054
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201

  Publications

Jarsky, Tim; Mady, Rina; Kennedy, Benjamin et al. (2008) Distribution of bursting neurons in the CA1 region and the subiculum of the rat hippocampus. J Comp Neurol 506:535-47
Jarsky, Tim; Roxin, Alex; Kath, William L et al. (2005) Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nat Neurosci 8:1667-76
Metz, Alexia E; Jarsky, Tim; Martina, Marco et al. (2005) R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons. J Neurosci 25:5763-73