18. GOALS FOR FELLOWSHIP TRAINING AND CAREER The following goals are designed with the intent of preparing me for a faculty position at a research and teaching institution. 1. Complete degree in less than 5 years. 2. Learn multiple experimental techniques. 3. Develop scientific reading and writing skills. 4. Secure a post-doctoral position prior to completion of degree. 5. Publish results prior to leaving lab. 6. Present results at a conference. SPONSOR 19. NAME AND DEGREE(S) Nelson Spruston_ PhD 20. POSITION/RANK Associate Professor 21. RESEARCH INTERESTS/AREAS Acitve dendritic integration i role of active processes in sTnaptic plastici ,ty / / / / II 22. DESCRIPTION (Do not exceed space provided) This study proposes to explore the role of voltage activated Ca2*channels in spike-firing mode of subicular neurons and whether spike-firing mode can influence the induction of plasticity. Specifically, I propose a series of pharmacological experiments to discem the relative roles of the various high voltage activated Ca 2* channels in the Ca2+-tafl current that drives bursting in subicular neurons of the hippocampus. The presence of the pharmacologically identified Ca 2 channels will be confirmed using molecular techniques. Finally, I will explore the effect of differences in spike-firing mode on the induction of LTP. PHS 416-1 (Rev. 12/98) Form Page 2 BB cc Individual NRSA Application Table of Contents ========================================Section End===========================================
| Jarsky, Tim; Mady, Rina; Kennedy, Benjamin et al. (2008) Distribution of bursting neurons in the CA1 region and the subiculum of the rat hippocampus. J Comp Neurol 506:535-47 |
| Jarsky, Tim; Roxin, Alex; Kath, William L et al. (2005) Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nat Neurosci 8:1667-76 |
| Metz, Alexia E; Jarsky, Tim; Martina, Marco et al. (2005) R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons. J Neurosci 25:5763-73 |
