Regulation of AMPAR synaptic clustering is important for establishing excitatory neurotransmission in development and for controlling the number of synaptic AMPARs during synaptic plasticity. Targeting of AMPARs to synaptic sites requires stargazin-PDZ protein interaction. nPIST, a PDZ protein, interacts with stargazin/AMPARs and is found in both the Golgi apparatus and the synapse, where it interacts with synaptic molecules such as glutamate receptor GluRd2. As such, nPIST is an excellent candidate for chaperoning the stargazin/AMPAR complex from the Golgi apparatus to the synapse, and may play a critical role in modulation of AMPAR synaptic clustering in plasticity. The goal of this proposal is to characterize the mechanisms by which nPIST regulates AMPAR synaptic delivery. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Predoctoral Individual National Research Service Award (F31)
Project #
5F31NS052927-02
Application #
7121938
Study Section
Special Emphasis Panel (ZRG1-F08 (29))
Program Officer
Talley, Edmund M
Project Start
2005-09-01
Project End
2008-05-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$38,005
Indirect Cost
Name
Northwestern University at Chicago
Department
Physiology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611