Effects of Alkylating Agents on DNA Repair

Trey, Joan E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 1F32CA007912-01
• Application #: 3032860
• Study Section: (BI)
• Project Start: 1986-01-03
• Budget Start: 1985-07-01
• Budget End: 1986-06-30
• Support Year: 1
• Fiscal Year: 1985

Institution

• Name: Case Western Reserve University
• Type: Schools of Medicine
• DUNS #: 077758407
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44106

Publications

Trey, J E; Gerson, S L (1989) The role of O6-alkylguanine DNA alkyltransferase in limiting nitrosourea-induced sister chromatid exchanges in proliferating human lymphocytes. Cancer Res 49:1899-903

Gerson, S L (1988) Regeneration of O6-alkylguanine-DNA alkyltransferase in human lymphocytes after nitrosourea exposure. Cancer Res 48:5368-73

Gerson, S L; Trey, J E; Miller, K (1988) Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase. Cancer Res 48:1521-7

Gerson, S L; Trey, J E; Miller, K et al. (1987) Repair of O6-alkylguanine during DNA synthesis in murine bone marrow hematopoietic precursors. Cancer Res 47:89-95