This Mentored Research Scientist Development Award (K01) application requests support for five years to investigate how risk and protective factors combine to put pre-teens at some overall drug use liability level. Many risk and protective factors pertaining to drug use, and dependence have been identified, however, few studies have investigated the association between risk factors among children prior to their first ingestion of drugs and later drug use, abuse, and dependence. Even fewer studies have examined how the various risk and protective factors combine to put individuals at some overall risk for (liability to) substance use. Under the mentorship of experts in psychopathological assessment, this study would a) develop a computer-administered instrument titled the Assessment of Liability and EXposure to Substance Use (ALEXSU) and b) prospectively test competing models of drug misuse liability. The ALEXSU would a) not require minimum reading or writing levels, b) be computerized because computer- based assessments of drug abuse generate increased reporting of substance use (Reich, et al., 1995; Turner, et al., 1998), and c) be enhanced with developmentally appropriate and culturally neutral graphics. The research plan proposes to a) develop the ALEXSU from existing measures designed for older individuals, b) investigate the ALEXSU's one-week test-retest reliability among 9 to 12 year old children, c) investigate how well ALEXSU scores predict stages of use and drug-related psychiatric symptoms for a variety of legal and illicit substances two years later and d) test three competing models of drug use liability against each other against a model that combines them, and against a simple summation score of the number of risk factors that participants report. Samples represent high- and low-risk populations. Small-scale validity studies of the ALEXSU will be conducted. Competing liability models will be compared in terms of how accurately they predict three drug use variables (having tried a drug, stage of drug use, and having an abuse or dependence symptom) at the two-year follow-up. The execution of the proposed research plan, formal coursework, and mentoring from the Sponsor and Co-Preceptors will facilitate the Applicant's a) transition in scientific focus to substance use, abuse, and dependence; b) acquisition of advanced analytical skills regarding substance use assessment and d) a platform from which to pursue a career of independently funded substance use research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA000434-02
Application #
6378313
Study Section
Special Emphasis Panel (ZDA1-KXA-N (21))
Program Officer
Conway, Kevin P
Project Start
2000-08-16
Project End
2005-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
2
Fiscal Year
2001
Total Cost
$107,992
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Halliburton, Amanda E; Ridenour, Ty A; White, Bradley A et al. (2017) Clinically differentiating life-course-persistent and adolescence-limited conduct problems: Is age-of-onset really enough? J Appl Dev Psychol 52:34-45
Ridenour, Ty A; Willis, David; Bogen, Debra L et al. (2015) Detecting initiation or risk for initiation of substance use before high school during pediatric well-child check-ups. Drug Alcohol Depend 150:54-62
Ridenour, Ty A; Meyer-Chilenski, Sarah; Reid, Erin E (2012) Developmental momentum toward substance dependence: natural histories and pliability of risk factors in youth experiencing chronic stress. Drug Alcohol Depend 123 Suppl 1:S87-98
Ridenour, Ty A; Caldwell, Linda L; Coatsworth, J Douglas et al. (2011) Directionality Between Tolerance of Deviance and Deviant Behavior is Age-Moderated in Chronically Stressed Youth. J Child Adolesc Subst Abuse 2:184-204
Ridenour, Ty A; Minnes, Sonia; Maldonado-Molina, Mildred M et al. (2011) Psychometrics and Cross-Cultural Comparisons of the Illustration-Based Assessment of Liability and Exposure to Substance Use and Antisocial Behavior© for Children. Open Fam Stud J 4:17-26
Conrad, Kelly L; Tseng, Kuei Y; Uejima, Jamie L et al. (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-21
Ghitza, Udi E; Nair, Sunila G; Golden, Sam A et al. (2007) Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model. J Neurosci 27:11522-32
Bossert, Jennifer M; Poles, Gabriela C; Wihbey, Kristina A et al. (2007) Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. J Neurosci 27:12655-63
Ridenour, Ty A; Feinberg, Mark E (2007) Using correlational analyses to improve prevention strategies based on survey data from youth. Eval Program Plann 30:36-44
Nair, S G; Gray, S M; Ghitza, U E (2006) Role of food type in yohimbine- and pellet-priming-induced reinstatement of food seeking. Physiol Behav 88:559-66

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