Between 1994 and 1998, I earned a doctoral degree in epidemiology. During the past two years I have conducted research on the influence of pregnancy and behavioral factors on women's health and the etiology of obesity as a research scientist at Kaiser Permanente. My career goals are to examine the effects of pregnancy on the risk of cardiovascular disease (CVD) and type 2 diabetes, and to expand my knowledge of genetic epidemiology. I am also interested in whether cumulative endogenous and exogenous reproductive hormone exposures (e.g., age at menarche, and hormonal contraceptive use) confound these relationships. To obtain research experience and training I plan to: 1. Use existing, computerized longitudinal databases to characterize pregnancy's long-term effects on changes in risk factors for CVD and type 2 diabetes among women of reproductive age. 2. Under the direction of my mentors; expand my knowledge of methodologies used to analyze longitudinal data. 3. Pursue independent study in genetic epidemiology with Dr. Neil Risch and conduct analyses using two databases to examine correlations of risk factors for female siblings and twins. 4. Attend workshops to acquire skills in writing grants, and courses in ethical conduct of research. Develop new R01 proposals based on the preliminary findings from the proposed analyses. A major strength of conducting research at Kaiser Permanente is the access to databases containing follow-up data on large cohorts of young women. I propose to utilize the Coronary Artery Risk Development in Young Adults (CARDIA) Study database and other databases to evaluate the following hypotheses: 1. Is having a first birth during follow-up associated with more unfavorable changes in risk factors for CVD and type 2 diabetes compared with never having given birth? 2. Is the relationship altered by use (duration or dose) of hormonal contraceptives? 3. Do the effects of pregnancy on changes in risk factors differ by race (White vs Blacks), or baseline BMI(< 25 vs > 25)? 4. For parous women, is gestational gain positively associated with postpartum BMI and WHR?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Scientist Development Award - Research &amp; Training (K01)
Project #
5K01DK059944-03
Application #
6736277
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Hyde, James F
Project Start
2002-05-01
Project End
2005-09-29
Budget Start
2004-05-01
Budget End
2005-09-29
Support Year
3
Fiscal Year
2004
Total Cost
$132,963
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
Lane-Cordova, Abbi D; Gunderson, Erica P; Carnethon, Mercedes R et al. (2018) Pre-pregnancy endothelial dysfunction and birth outcomes: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Hypertens Res 41:282-289
Gunderson, Erica P; Lewis, Cora E; Lin, Ying et al. (2018) Lactation Duration and Progression to Diabetes in Women Across the Childbearing Years: The 30-Year CARDIA Study. JAMA Intern Med 178:328-337
Lane-Cordova, A D; Carnethon, M R; Catov, J M et al. (2018) Cardiorespiratory fitness, exercise haemodynamics and birth outcomes: the Coronary Artery Risk Development in Young Adults Study. BJOG 125:1127-1134
Catov, Janet M; Snyder, Gabrielle G; Fraser, Abigail et al. (2018) Blood Pressure Patterns and Subsequent Coronary Artery Calcification in Women Who Delivered Preterm Births. Hypertension 72:159-166
Dehmer, Elizabeth W; Phadnis, Milind A; Gunderson, Erica P et al. (2018) Association Between Gestational Diabetes and Incident Maternal CKD: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Kidney Dis 71:112-122
Whitaker, Kara M; Ingram, Katherine H; Appiah, Duke et al. (2018) Prepregnancy Fitness and Risk of Gestational Diabetes: A Longitudinal Analysis. Med Sci Sports Exerc 50:1613-1619
Lane-Cordova, Abbi D; Puterman, Eli; Gunderson, Erica P et al. (2017) Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study. PLoS One 12:e0186495
Catov, Janet M; Althouse, Andrew D; Lewis, Cora E et al. (2016) Preterm Delivery and Metabolic Syndrome in Women Followed From Prepregnancy Through 25 Years Later. Obstet Gynecol 127:1127-34
Ajmera, Veeral H; Gunderson, Erica P; VanWagner, Lisa B et al. (2016) Gestational Diabetes Mellitus Is Strongly Associated With Non-Alcoholic Fatty Liver Disease. Am J Gastroenterol 111:658-64
Appiah, Duke; Schreiner, Pamela J; Gunderson, Erica P et al. (2016) Association of Gestational Diabetes Mellitus With Left Ventricular Structure and Function: The CARDIA Study. Diabetes Care 39:400-7

Showing the most recent 10 out of 39 publications