Application) To prevent cancer, one must have identified the critical exposure. Increasing evidence suggest that childhood and adolescence are a particularly vulnerable period for mutagenic exposures. Furthermore, to motivate behavior change, one must effectively communicate risk. The specific research aims of this proposal are therefore to:1) Examine the relation between adolescent exposures and the subsequent development of adult malignancies. 2) To construct a model of overall cancer incidence and mortality that can be used to: a) define the attributable risk of each exposure, comparing adolescent versus adult exposures. b) define interactions between exposures (how much worse is one's risk of cancer if one never eats fruits or vegetables and is a heavy drinker?). c)estimate the efficacy of a cancer prevention intervention at both the individual and societal level. These objectives will be accomplished using the data collected by the Nurses' Health Study, a prospective cohort of 121,700 women prospectively followed since 1976. Extensive, validated data have been collected every two years on significant exposures, diet and incidence of disease. Follow-up of the initial cohort as of 1990 was over 91 percent.As a recipient of a Preventive Oncology Academic Award, I would seek more didactic training in the methods of epidemiology, biostatistics and risk modification at the Harvard School of Public Health to further refine my work in cancer prevention.
| Cannuscio, Carolyn C; Colditz, Graham A; Rimm, Eric B et al. (2004) Employment status, social ties, and caregivers' mental health. Soc Sci Med 58:1247-56 |
| Frazier, A Lindsay; Ryan, Catherine Tomeo; Rockett, Helaine et al. (2003) Adolescent diet and risk of breast cancer. Breast Cancer Res 5:R59-64 |
| Frazier, A Lindsay; Ryan, Catherine Tomeo; Rockett, Helaine et al. (2003) Adolescent diet and risk of breast cancer. Breast Cancer Res 5:R59-64 |
| Frazier, A L; Colditz, G A; Fuchs, C S et al. (2000) Cost-effectiveness of screening for colorectal cancer in the general population. JAMA 284:1954-61 |
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| Colditz, G A; Cannuscio, C C; Frazier, A L (1997) Physical activity and reduced risk of colon cancer: implications for prevention. Cancer Causes Control 8:649-67 |
| Frazier, A L; Grier, H E; Green, D M (1996) Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin. Med Pediatr Oncol 27:69-73 |
| Frazier, A L; Willett, W C; Colditz, G A (1995) Reproducibility of recall of adolescent diet: Nurses' Health Study (United States). Cancer Causes Control 6:499-506 |
| Colditz, G A; Frazier, A L (1995) Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol Biomarkers Prev 4:567-71 |
