Clinical management of an aging population with its increased prevalence of vascular disease will present future challenges to the medical profession. Availability of a constellation of clinically relevant specialties will required for the efficient delivery of care to these patients. Currently, clinical management of vascular disease is not well focused and lacks interdisciplinary participation in many instances. As a result, management been diffused, institutions frequently have lacked central themes, and an awareness of vascular disease among students and trainees has been acknowledged as poor. This proposal outlined in the candidate's application seeks to coordinate a defined multidisciplinary program for the management of vascular disease. The proposal, takes advantage of the existing facilities and specialists who are committed to the development of an integrated program. Five specific goals have been targeted to accomplish the aims of this proposal: 1. Development and maturation of the Center for Vascular Disease which will utilize existing facilities and staff. Growth and recognition of this facility will provide a focus for developing a multispecialty approach for the care of patients with vascular disease. 2. To coordinate research activities in vascular biology through a Vascular Research Committee composed of basic and clinical scientists. 3. To establish an integrated educational program in vascular disease for students, nurses, houseofficers, fellows and faculty, an Education Committee for Vascular Disease will be appointed to coordinate these activities with the goal of heightening awareness of vascular disease. 4. To establish a Fellowship in Vascular Medicine, which will include opportunities for research as well as clinical management of vascular disease. 5. To prepare and publish Guidelines for the Management of Vascular Disease, which will outline current standards of care as well as recommendations for complex clinical decisions. Successful implementation of these aims will contribute to the achievement of the objectives outlined by e Public Health Service in its """"""""Healthy People 2000"""""""" initiative.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Academic/Teacher Award (ATA) (K07)
Project #
5K07HL003437-05
Application #
6043664
Study Section
Special Emphasis Panel (ZHL1-CSR-Y (M1))
Project Start
1995-09-15
Project End
2000-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Surgery
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Aramoto, Haruo; Breslin, Jerome W; Pappas, Peter J et al. (2004) Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation. Am J Physiol Heart Circ Physiol 287:H1590-8
Breslin, Jerome W; Pappas, Peter J; Cerveira, Joaquim J et al. (2003) VEGF increases endothelial permeability by separate signaling pathways involving ERK-1/2 and nitric oxide. Am J Physiol Heart Circ Physiol 284:H92-H100
Varma, Shubha; Breslin, Jerome W; Lal, Brajesh K et al. (2002) p42/44MAPK regulates baseline permeability and cGMP-induced hyperpermeability in endothelial cells. Microvasc Res 63:172-8
Saito, S; Trovato, M J; You, R et al. (2001) Role of matrix metalloproteinases 1, 2, and 9 and tissue inhibitor of matrix metalloproteinase-1 in chronic venous insufficiency. J Vasc Surg 34:930-8
Lal, B K; Varma, S; Pappas, P J et al. (2001) VEGF increases permeability of the endothelial cell monolayer by activation of PKB/akt, endothelial nitric-oxide synthase, and MAP kinase pathways. Microvasc Res 62:252-62
Kissin, M; Kansal, N; Pappas, P J et al. (2000) Vein interposition cuffs decrease the intimal hyperplastic response of polytetrafluoroethylene bypass grafts. J Vasc Surg 31:69-83
Hanna, A K; Duran, W N; Leconte, I et al. (2000) Adenoviral-mediated expression of antisense RNA to basic fibroblast growth factor reduces tangential stress in arterialized vein grafts. J Vasc Surg 31:770-80
Padberg Jr, F T; Maniker, A H; Carmel, G et al. (1999) Sensory impairment: a feature of chronic venous insufficiency. J Vasc Surg 30:836-42
Pappas, P J; You, R; Rameshwar, P et al. (1999) Dermal tissue fibrosis in patients with chronic venous insufficiency is associated with increased transforming growth factor-beta1 gene expression and protein production. J Vasc Surg 30:1129-45
Curi, M A; Pappas, P J; Silva Jr, M B et al. (1999) Hemodialysis access: influence of the human immunodeficiency virus on patency and infection rates. J Vasc Surg 29:608-16

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