Activation of Prostate Specific Antigen Precursor

Takayama, Thomas K.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Clinical Investigator Award (CIA) (K08)
• Project #: 1K08DK002447-01
• Application #: 2134392
• Study Section: Special Emphasis Panel (SRC)
• Project Start: 1996-07-15
• Project End: 2001-06-30
• Budget Start: 1996-07-15
• Budget End: 1997-06-30
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: University of Washington
• Department: Urology
• Type: Schools of Medicine
• DUNS #: 135646524
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Greenberg, Daniel L; Mize, Gregory J; Takayama, Thomas K (2003) Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. Biochemistry 42:702-9

Takayama, T K; Carter, C A; Deng, T (2001) Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR. Biochemistry 40:1679-87

Cooley, J; Takayama, T K; Shapiro, S D et al. (2001) The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry 40:15762-70

Takayama, T K; McMullen, B A; Nelson, P S et al. (2001) Characterization of hK4 (prostase), a prostate-specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry 40:15341-8

Takayama, T K; Fujikawa, K; Davie, E W (1997) Characterization of the precursor of prostate-specific antigen. Activation by trypsin and by human glandular kallikrein. J Biol Chem 272:21582-8