Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Clinical Investigator Award (CIA) (K08)
Project #
5K08HL002681-05
Application #
2210366
Study Section
Research Manpower Review Committee (MR)
Project Start
1991-09-30
Project End
1997-09-29
Budget Start
1995-09-30
Budget End
1997-09-29
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Temple University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Selim, T E; Ghoneim, H R; Abdel Ghaffar, H A et al. (2001) High molecular mass kininogen inhibits cathepsin G-induced platelet activation by forming a complex with cathepsin G. Hematol J 2:371-7
Majluf-Cruz, A; Manns, J M; Uknis, A B et al. (2000) Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: evaluation by two novel binding assays. J Lab Clin Med 136:292-302
DeLa Cadena, R A; Majluf-Cruz, A; Stadnicki, A et al. (1998) Recombinant tumor necrosis factor receptor p75 fusion protein (TNFR:Fc) alters endotoxin-induced activation of the kinin, fibrinolytic, and coagulation systems in normal humans. Thromb Haemost 80:114-8
Kaplan, R; DeLa Cadena, R A (1998) Mechanism of the coagulopathy associated with acute promyelocytic leukemia -clinical conference-. Am J Hematol 59:234-7
Khan, M M; Kunapuli, S P; Lin, Y et al. (1998) Three noncontiguous peptides comprise binding sites on high-molecular-weight kininogen to neutrophils. Am J Physiol 275:H145-50
DeLa Cadena, R A; Kunapuli, S P; Walz, D A et al. (1998) Expression of thrombospondin 1 on the surface of activated platelets mediates their interaction with the heavy chains of human kininogens through Lys 244-Pro 254. Thromb Haemost 79:186-94
Selim, T E; Ghoneim, H R; Uknis, A B et al. (1997) High-molecular-mass and low-molecular-mass kininogens block plasmin-induced platelet aggregation by forming a complex with kringle 5 of plasminogen/plasmin. Eur J Biochem 250:532-8
Bradford, H N; Dela Cadena, R A; Kunapuli, S P et al. (1997) Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. Blood 90:1508-15
Chouhan, V D; De La Cadena, R A; Nagaswami, C et al. (1997) Simultaneous occurrence of human antibodies directed against fibrinogen, thrombin, and factor V following exposure to bovine thrombin: effects on blood coagulation, protein C activation and platelet function. Thromb Haemost 77:343-9
Dela Cadena, R A; Stadnicki, A; Uknis, A B et al. (1995) Inhibition of plasma kallikrein prevents peptidoglycan-induced arthritis in the Lewis rat. FASEB J 9:446-52

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