Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Physician Scientist Award (K11)
Project #
5K11AI000929-02
Application #
3085298
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Project Start
1989-04-01
Project End
1990-06-30
Budget Start
1990-04-01
Budget End
1990-06-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Alfano, Randall W; Leppla, Stephen H; Liu, Shihui et al. (2008) Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Mol Cancer Ther 7:1218-26
Gupta, Pradeep K; Liu, Shihui; Batavia, Mariska P et al. (2008) The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin. Cell Microbiol 10:1687-94
Wickliffe, Katherine E; Leppla, Stephen H; Moayeri, Mahtab (2008) Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome. Cell Microbiol 10:332-43
Liu, Shihui; Wang, Hailun; Currie, Brooke M et al. (2008) Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem 283:529-40
Chen, Kuang-Hua; Liu, Shihui; Bankston, Laurie A et al. (2007) Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells. J Biol Chem 282:9834-45
Liu, Shihui; Leung, Howard J; Leppla, Stephen H (2007) Characterization of the interaction between anthrax toxin and its cellular receptors. Cell Microbiol 9:977-87
Liu, Shihui; Redeye, Vivien; Kuremsky, Jeffrey G et al. (2005) Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol 23:725-30
McFarland, E J; Harding, P A; Luckey, D et al. (1994) High frequency of Gag- and envelope-specific cytotoxic T lymphocyte precursors in children with vertically acquired human immunodeficiency virus type 1 infection. J Infect Dis 170:766-74
McFarland, E J; Curiel, T J; Schoen, D J et al. (1993) Cytotoxic T lymphocyte lines specific for human immunodeficiency virus type 1 Gag and reverse transcriptase derived from a vertically infected child. J Infect Dis 167:719-23