The lifecourse approach to chronic disease proposes that factors operating not only in adult life, but also from conception, have impact on lifelong health. Among the more publicized findings in this area are associations between lower birth weight and adult cardiovascular disease mortality, incidence, and risk factors such as blood pressure. These newer investigations have led to a series of exciting research questions and opportunities concerning underlying mechanisms, relations of pre- and post-natal determinants, and implications for clinical medicine and public health. This proposed K24 award will allow Dr. Gillman and his mentees to focus intensively on this area of research for the next five years, a critical period not only for the field itself, but also for expanding his potential for significant contributions and for nurturing the next generation of patient-oriented researchers in this field.
The specific aims of this proposal are 1. Research project to examine associations among maternal gestational protein intake, placental hormone activity, and blood pressure in the offspring. This project will take advantage of the infrastructure provided by an ongoing NIH-funded prospective cohort study of pregnant women and their offspring (Project Viva). 2. To provide a nourishing professional environment for the training and advancement of beginning clinical researchers, who will conduct and analyze data from Project Viva and other ongoing patient-oriented research studies in the area of the lifecourse approach to chronic disease. Major foci will be in the areas of pregnancy and infancy determinants of a. childhood cardiovascular risk factors, chiefly blood pressure, b. asthma in early childhood, and c. development of obesity in childhood and adolescence.
| Bunyavanich, Supinda; Rifas-Shiman, Sheryl L; Platts-Mills, Thomas A et al. (2016) Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. J Allergy Clin Immunol 137:1063-1070.e2 |
| Gaillard, Romy; Rifas-Shiman, Sheryl L; Perng, Wei et al. (2016) Maternal inflammation during pregnancy and childhood adiposity. Obesity (Silver Spring) 24:1320-7 |
| Perng, Wei; Rifas-Shiman, Sheryl L; Rich-Edwards, Janet W et al. (2016) Inflammation and weight gain in reproductive-aged women. Ann Hum Biol 43:91-5 |
| Belfort, Mandy B; Rifas-Shiman, Sheryl L; Kleinman, Ken P et al. (2016) Infant Breastfeeding Duration and Mid-Childhood Executive Function, Behavior, and Social-Emotional Development. J Dev Behav Pediatr 37:43-52 |
| Haines, Jess; Rifas-Shiman, Sheryl L; Gross, Deborah et al. (2016) Randomized trial of a prevention intervention that embeds weight-related messages within a general parenting program. Obesity (Silver Spring) 24:191-9 |
| Sonneville, Kendrin R; Long, Michael W; Rifas-Shiman, Sheryl L et al. (2015) Juice and water intake in infancy and later beverage intake and adiposity: could juice be a gateway drink? Obesity (Silver Spring) 23:170-6 |
| Field, Alison E; Sonneville, Kendrin R; Crosby, Ross D et al. (2014) Prospective associations of concerns about physique and the development of obesity, binge drinking, and drug use among adolescent boys and young adult men. JAMA Pediatr 168:34-9 |
| Emmons, Karen M; Puleo, Elaine; Greaney, Mary L et al. (2014) A randomized comparative effectiveness study of Healthy Directions 2--a multiple risk behavior intervention for primary care. Prev Med 64:96-102 |
| Regnault, Nolwenn; Kleinman, Ken P; Rifas-Shiman, Sheryl L et al. (2014) Components of height and blood pressure in childhood. Int J Epidemiol 43:149-59 |
| Burris, Heather H; Rifas-Shiman, Sheryl L; Huh, Susanna Y et al. (2014) Vitamin D status and hypertensive disorders in pregnancy. Ann Epidemiol 24:399-403.e1 |
Showing the most recent 10 out of 145 publications
