Abstract

We have established the UCSD Clinical and Translational Research Institute (CTRI), with its hub located at the University of California, San Diego (UCSD). This regional center includes three universities (UCSD, San Diego State University and UC Riverside), 4 biomedical research institutes (Salk Institute, Sanford-Burnham Institute, J. Craig Venter Institute, and La Jolla Institute for Allergy and Immunology), and 3 academic hospitals (UCSD Medical Center, VA San Diego Medical Center and Rady Children's Hospital), one community health center (Palomar Health). The CTSA program encompasses 3 health sciences professional schools (Medicine, Pharmacy, and Nursing) and 2 Master's programs in Clinical Research and Drug Discovery Sciences. The overall program goals are to: 1) Develop an integrated education and training program across the translational science spectrum; 2) Empower community-based partnerships and integrate the stakeholders into translational research governance; 3) Diversify and enhance biomedical informatics infrastructure to provide a secure, confidential and inter-operative platform; 4) Provide administrative infrastructure to manage and improve clinical and translational research; and 5) Provide resources that enhance collaboration, encourage disruptive innovation and support clinical investigation. The CTRI KL2 program will provide a mentored research experience for junior faculty that ensures a diverse future workforce with the required skills for outstanding multi-disciplinary research in human health. Didactic programs will teach key skills in clinical and translational research, including Master's degrees for individuals seeking additional rigor. Mini-sabbaticals will offer experiential training to enhance the scholars' research programs. A Mentoring Core will train scholars to become mentors for the next generation of researchers. Outcomes and tracking will use new informatics tools to determine the impact of the curriculum on long term research productivity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
1KL2TR001444-01
Application #
9085735
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Brazhnik, Olga
Project Start
2015-08-13
Project End
2020-03-31
Budget Start
2015-08-13
Budget End
2016-03-31
Support Year
1
Fiscal Year
2015
Total Cost
$1,320,077
Indirect Cost
$96,154

  Institution

Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Thomas, Isac C; Thompson, Caroline A; Yang, Mingan et al. (2018) Thoracic Aorta Calcification and Noncardiovascular Disease-Related Mortality. Arterioscler Thromb Vasc Biol 38:1926-1932
Seibert, Tyler M; Dalia, Yoseph; Karunamuni, Roshan et al. (2018) Unilateral hippocampal wasting after combined-modality therapy for glioblastoma. Acta Oncol 57:688-691
Murzin, Vyacheslav L; Woods, Kaley; Moiseenko, Vitali et al. (2018) 4? plan optimization for cortical-sparing brain radiotherapy. Radiother Oncol 127:128-135
Debnath, Anjan; Nelson, Andrew T; Silva-Olivares, Angélica et al. (2018) In Vitro Efficacy of Ebselen and BAY 11-7082 AgainstNaegleria fowleri. Front Microbiol 9:414
Thompson, Caroline A; Boothroyd, Derek B; Hastings, Katherine G et al. (2018) A Multiple-Imputation ""Forward Bridging"" Approach to Address Changes in the Classification of Asian Race/Ethnicity on the US Death Certificate. Am J Epidemiol 187:347-357
Kumar, Sumit; Bains, Trpta; Won Kim, Ashley Sae et al. (2018) Highly Potent 1H-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Sexually-Transmitted Protozoal Parasites. Front Cell Infect Microbiol 8:380
Battat, Robert; Duijvestein, Marjolijn; Vande Casteele, Niels et al. (2018) Serum Concentrations of 7?-hydroxy-4-cholesten-3-one are Associated with Bile Acid Diarrhea in Patients with Crohn's Disease. Clin Gastroenterol Hepatol :
Jacobus, Joanna; Taylor, Charles T; Gray, Kevin M et al. (2018) A multi-site proof-of-concept investigation of computerized approach-avoidance training in adolescent cannabis users. Drug Alcohol Depend 187:195-204
Zyserman, Ingrid; Mondal, Deboprosad; Sarabia, Francisco et al. (2018) Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Exp Parasitol 188:36-41
Swerdlow, Neal R; Bhakta, Savita G; Talledo, Jo A et al. (2018) Effects of Amphetamine on Sensorimotor Gating and Neurocognition in Antipsychotic-Medicated Schizophrenia Patients. Neuropsychopharmacology 43:708-717

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