Abstract

We have established the UCSD Clinical and Translational Research Institute (CTRI), with its hub located at the University of California, San Diego (UCSD). This regional center includes three universities (UCSD, San Diego State University and UC Riverside), 4 biomedical research institutes (Salk Institute, Sanford-Burnham Institute, J. Craig Venter Institute, and La Jolla Institute for Allergy and Immunology), and 3 academic hospitals (UCSD Medical Center, VA San Diego Medical Center and Rady Children's Hospital), one community health center (Palomar Health). The CTSA program encompasses 3 health sciences professional schools (Medicine, Pharmacy, and Nursing) and 2 Master's programs in Clinical Research and Drug Discovery Sciences. The overall program goals are to: 1) Develop an integrated education and training program across the translational science spectrum; 2) Empower community-based partnerships and integrate the stakeholders into translational research governance; 3) Diversify and enhance biomedical informatics infrastructure to provide a secure, confidential and inter-operative platform; 4) Provide administrative infrastructure to manage and improve clinical and translational research; and 5) Provide resources that enhance collaboration, encourage disruptive innovation and support clinical investigation. The CTRI KL2 program will provide a mentored research experience for junior faculty that ensures a diverse future workforce with the required skills for outstanding multi-disciplinary research in human health. Didactic programs will teach key skills in clinical and translational research, including Master's degrees for individuals seeking additional rigor. Mini-sabbaticals will offer experiential training to enhance the scholars' research programs. A Mentoring Core will train scholars to become mentors for the next generation of researchers. Outcomes and tracking will use new informatics tools to determine the impact of the curriculum on long term research productivity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR001444-03
Application #
9262308
Study Section
Special Emphasis Panel (ZTR1-SRC (99))
Program Officer
Brazhnik, Olga
Project Start
2015-08-13
Project End
2020-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
3
Fiscal Year
2017
Total Cost
$1,441,904
Indirect Cost
$94,760

  Institution

Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Wang, Winnie S; Ma, Joseph D; Nelson, Sandahl H et al. (2018) Transfusion practices at end of life for hematopoietic stem cell transplant patients. Support Care Cancer 26:1927-1931
Dulai, Parambir S; Boland, Brigid S; Singh, Siddharth et al. (2018) Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients With Crohn's Disease. Gastroenterology 155:687-695.e10
Carlin, Aaron F; Vizcarra, Edward A; Branche, Emilie et al. (2018) Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. Proc Natl Acad Sci U S A 115:E9172-E9181
Garcia-Carbonell, Ricard; Wong, Jerry; Kim, Ju Youn et al. (2018) Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A 115:E9192-E9200
Bandoli, Gretchen; Palmsten, Kristin; Chambers, Christina D et al. (2018) Revisiting the Table 2 fallacy: A motivating example examining preeclampsia and preterm birth. Paediatr Perinat Epidemiol 32:390-397
Lesser, Lenard I; Thompson, Caroline A; Luft, Harold S (2018) Association Between Monetary Deposits and Weight Loss in Online Commitment Contracts. Am J Health Promot 32:198-204
Depp, Colin A; Howland, Alex; Dumbauld, Jill et al. (2018) Development of a game-based learning tool for applied team science communication in a virtual clinical trial. J Clin Transl Sci 2:169-172
Moustafa, Ahmed; Li, Weizhong; Anderson, Ericka L et al. (2018) Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease. Clin Transl Gastroenterol 9:e132
Lombardo, M V; Moon, H M; Su, J et al. (2018) Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder. Mol Psychiatry 23:1001-1013
Jarrad, Angie M; Ang, Chee Wei; Debnath, Anjan et al. (2018) Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity. J Med Chem :

Showing the most recent 10 out of 87 publications