Project Start
1988-01-04
Project End
1993-01-03
Budget Start
1990-09-11
Budget End
1991-01-03
Support Year
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Alabama in Tuscaloosa
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Tuscaloosa
State
AL
Country
United States
Zip Code
35487
Morgan, M E; Chi, S C; Murakami, K et al. (1992) Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs. Antimicrob Agents Chemother 36:2156-65
Hoesterey, B L; Galinsky, R E; Anderson, B D (1991) Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats. Drug Metab Dispos 19:907-12
Galinsky, R E; Flaharty, K K; Hoesterey, B L et al. (1991) Probenecid enhances central nervous system uptake of 2',3'-dideoxyinosine by inhibiting cerebrospinal fluid efflux. J Pharmacol Exp Ther 257:972-8
Galinsky, R E; Hoesterey, B L; Anderson, B D (1990) Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injection. Life Sci 47:781-8
Anderson, B D; Hoesterey, B L; Baker, D C et al. (1990) Uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats: intravenous infusion studies. J Pharmacol Exp Ther 253:113-8