Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM047019-000
Application #
3701112
Study Section
Project Start
1993-11-01
Project End
1997-09-30
Budget Start
1993-11-01
Budget End
1993-12-31
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Auckland Uniservices, Ltd
Department
Type
DUNS #
City
Auckland
State
Country
New Zealand
Zip Code
Lee, A E; Wilson, W R (2000) Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicol Appl Pharmacol 163:50-9
Siim, B G; Hicks, K O; Pullen, S M et al. (2000) Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism. Biochem Pharmacol 60:969-78
Perrin, L C; Wilson, W R; Denny, W A et al. (1999) The design of cobalt(III) complexes of phenazine-1-carboxamides as prointercalators and potential hypoxia-selective cytotoxins. Anticancer Drug Des 14:231-41
Sykes, B M; Atwell, G J; Hogg, A et al. (1999) N-Substituted 2-(2,6-dinitrophenylamino)propanamides: novel prodrugs that release a primary amine via nitroreduction and intramolecular cyclization. J Med Chem 42:346-55
Atwell, G J; Milbank, J J; Wilson, W R et al. (1999) 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits. J Med Chem 42:3400-11
Lee, H H; Wilson, W R; Denny, W A (1999) Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity. Anticancer Drug Des 14:487-97
Wilson, W R; Tercel, M; Anderson, R F et al. (1998) Radiation-activated prodrugs as hypoxia-selective cytotoxins: model studies with nitroarylmethyl quaternary salts. Anticancer Drug Des 13:663-85
Wilson, W R; Ferry, D M; Tercel, M et al. (1998) Reduction of nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine by radiation. Radiat Res 149:237-45
Wilson, W R; Li, A E; Cowan, D S et al. (1998) Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Int J Radiat Oncol Biol Phys 42:905-8
Ware, D C; Palmer, H R; Pruijn, F B et al. (1998) Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins. Anticancer Drug Des 13:81-103

Showing the most recent 10 out of 21 publications