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Lee, A E; Wilson, W R (2000) Hypoxia-dependent retinal toxicity of bioreductive anticancer prodrugs in mice. Toxicol Appl Pharmacol 163:50-9
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Siim, B G; Hicks, K O; Pullen, S M et al. (2000) Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism. Biochem Pharmacol 60:969-78
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Perrin, L C; Wilson, W R; Denny, W A et al. (1999) The design of cobalt(III) complexes of phenazine-1-carboxamides as prointercalators and potential hypoxia-selective cytotoxins. Anticancer Drug Des 14:231-41
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Sykes, B M; Atwell, G J; Hogg, A et al. (1999) N-Substituted 2-(2,6-dinitrophenylamino)propanamides: novel prodrugs that release a primary amine via nitroreduction and intramolecular cyclization. J Med Chem 42:346-55
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Atwell, G J; Milbank, J J; Wilson, W R et al. (1999) 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits. J Med Chem 42:3400-11
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Lee, H H; Wilson, W R; Denny, W A (1999) Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity. Anticancer Drug Des 14:487-97
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Ware, D C; Palmer, H R; Pruijn, F B et al. (1998) Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins. Anticancer Drug Des 13:81-103
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Lee, H H; Palmer, B D; Wilson, W R et al. (1998) Synthesis and hypoxia-selective cytotoxicity of a 2-nitroimidazole mustard. Bioorg Med Chem Lett 8:1741-4
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Lash, C J; Li, A E; Rutland, M et al. (1998) Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs. Br J Cancer 78:439-45
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Wilson, W R; Tercel, M; Anderson, R F et al. (1998) Radiation-activated prodrugs as hypoxia-selective cytotoxins: model studies with nitroarylmethyl quaternary salts. Anticancer Drug Des 13:663-85
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