Conduct toxicology studies in accordance with the complete protocol guidelines developed for each agent by the NCI Project Officer. Since it would be inappropriate to set rigid guidelines that would be adequate for each drug, the guidelines will be supplemented to take into account in- vitro cytotoxicity data, biochemical information and schedule dependency data.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM087259-004
Application #
3615866
Study Section
Project Start
1987-11-01
Project End
1992-10-14
Budget Start
1988-11-01
Budget End
1989-10-31
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205
Erickson-Miller, C L; May, R D; Tomaszewski, J et al. (1997) Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro. Cancer Chemother Pharmacol 39:467-72