Conduct toxicology studies in accordance with the complete protocol guidelines developed for each agent by the NCI Project Officer. Since it would be inappropriate to set rigid guidelines that would be adequate for each drug, the guidelines will be supplemented to take into account in- vitro cytotoxicity data, biochemical information and schedule dependency data.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Treatment (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CM087259-016
Application #
3615878
Study Section
Project Start
Project End
1992-10-31
Budget Start
1992-09-30
Budget End
1992-10-31
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205
Erickson-Miller, C L; May, R D; Tomaszewski, J et al. (1997) Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro. Cancer Chemother Pharmacol 39:467-72