Abstract

ORAU hosted a workshop sponsored by the NIH and ORAU to address the question, """"""""Is the Marmoset an Experimental Model forthe Study of Gastrointestinal Disease?"""""""". This program, held in April, 1984, considered the animal resource, colitis, and colon cancer in the cotton-topped marmoset. Participants discussed the overall value of the marmoset for the study of GI diseases. Many of the participants have initiated collaborative studies with ORAU to conduct the following studies involving the NCI animals: studies of coronavirus in the etiology of colitis; transformation of marmoset lymphocytes with HTLV-I and HTLV-II; studies of colon cancer; cytogenetic characterization of peripheral lymphocytes of marmosets; and determination of relative susceptibility of these marmosets to developing colon cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Research and Development Contracts (N01)
Project #
N01CP021004-007
Application #
3627247
Study Section
Project Start
1982-06-23
Project End
1985-06-22
Budget Start
1985-05-10
Budget End
1985-05-31
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Oak Ridge Associated Universities
Department
Type
DUNS #
City
Oak Ridge
State
TN
Country
United States
Zip Code
37831

  Publications

Clapp, N K; Henke, M L; Lushbaugh, C C et al. (1988) Effect of various biological factors on spontaneous marmoset and tamarin colitis. A retrospective histopathologic study. Dig Dis Sci 33:1013-9
Boland, C R; Clapp, N K (1987) Glycoconjugates in the colons of New World monkeys with spontaneous colitis. Association between inflammation and neoplasia. Gastroenterology 92:625-34
Tardif, S D (1985) Histologic evidence for age-related differences in ovarian function in tamarins (Saguinus sp.;primates). Biol Reprod 33:993-1000
Clapp, N K; Lushbaugh, C C; Humason, G L et al. (1985) The marmoset as a model of ulcerative colitis and colon cancer. Prog Clin Biol Res 186:247-61
Clapp, N K; Lushbaugh, C C; Humason, G L et al. (1985) Natural history and pathology of colon cancer in Saguinus oedipus oedipus. Dig Dis Sci 30:107S-113S
Lushbaugh, C; Humason, G; Clapp, N (1985) Histology of colon cancer in Saguinus oedipus oedipus. Dig Dis Sci 30:119S-125S
Russell, R G; Brian, D A; Lenhard, A et al. (1985) Coronavirus-like particles and Campylobacter in marmosets with diarrhea and colitis. Dig Dis Sci 30:72S-77S
Clapp, N K; Tardif, S D (1985) Marmoset husbandry and nutrition. Dig Dis Sci 30:17S-23S