The objective of this project is to determine the comparative efficacies of tin protoporphyrin (SnPP) and tin mesoporphyrin (SnMP) in decreasing the level of hyperbilirubinemia in preterm infants weighing 1500-2250 grms. at birth, as compared with untreated infants of the same birth weight groups. The study is to be carried out at Mitera Maternity Hospital in Athens, Greece, and infants meeting a set of eligibility criteria will be entered in the study after obtaining parental consent.
| Drummond, G S; Valaes, T; Kappas, A (1996) Control of bilirubin production by synthetic heme analogs: pharmacologic and toxicologic considerations. J Perinatol 16:S72-9 |
| Kappas, A; Drummond, G S; Henschke, C et al. (1995) Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns. Pediatrics 95:468-74 |
| Valaes, T; Petmezaki, S; Henschke, C et al. (1994) Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin. Pediatrics 93:1-11 |
