A major theme of this program project is the study of accessory cell function required for the stimulation of T helper cells. The two functions that are investigated are the expression and role of two key molecules: interleukin-1 and the class II histocompatibility molecules, or Ia molecules. Two of the projects deal with basic issues concerning some of the regulatory mechanisms that lead to IL-1 and Ia production by antigen presenting cells. Attempts are described to modulate Ia expression mainly by the use of by antibodies to interferon- gamma. The effects of this manipulation in the transplantation of allogeneic tissues is critically analyzed with a number of tissues. One of our objectives is to integrate the activity of basic immunobiologists with transplantation surgeons by creating a program where both activities are deeply interrelated for the benefit of both groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI024854-04
Application #
3091829
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1987-09-01
Project End
1992-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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