Abstract

A major theme of this program project is the study of accessory cell function required for the stimulation of T helper cells. The two functions that are investigated are the expression and role of two key molecules: interleukin-1 and the class II histocompatibility molecules, or Ia molecules. Two of the projects deal with basic issues concerning some of the regulatory mechanisms that lead to IL-1 and Ia production by antigen presenting cells. Attempts are described to modulate Ia expression mainly by the use of by antibodies to interferon- gamma. The effects of this manipulation in the transplantation of allogeneic tissues is critically analyzed with a number of tissues. One of our objectives is to integrate the activity of basic immunobiologists with transplantation surgeons by creating a program where both activities are deeply interrelated for the benefit of both groups.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI024854-05
Application #
3091830
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1987-09-01
Project End
1992-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Nett-Fiordalisi, M; Tomaselli, K; Russell, J H et al. (1995) Macrophage apoptosis in the absence of active interleukin-1 beta-converting enzyme. J Leukoc Biol 58:717-24
Mariathasan, S; Matsumoto, M; Baranyay, F et al. (1995) Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration. J Inflamm 45:72-8
Sheehan, K C; Pinckard, J K; Arthur, C D et al. (1995) Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med 181:607-17
Wall, D A; Sheehan, K C (1994) The role of tumor necrosis factor and interferon gamma in graft-versus-host disease and related immunodeficiency. Transplantation 57:273-9
Greenlund, A C; Schreiber, R D; Goeddel, D V et al. (1993) Interferon-gamma induces receptor dimerization in solution and on cells. J Biol Chem 268:18103-10
Nakafusa, Y; Goss, J A; Roland, C R et al. (1993) The effect of portal venous tolerance on the survival of small bowel allografts in the rat. Transplantation 56:1279-82
Farrar, M A; Schreiber, R D (1993) The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 11:571-611
Goss, J A; Nakafusa, Y; Yu, S et al. (1993) Intrathymic injection of donor alloantigens induces specific tolerance to cardiac allografts. Transplantation 56:166-73
Goss, J A; Nakafusa, Y; Flye, M W (1993) MHC class II presenting cells are necessary for the induction of intrathymic tolerance. Ann Surg 217:492-9;discussion 499-501
Gerasimidi, A; Sheehan, K C; Schreiber, R D et al. (1993) Tumor necrosis factor-alpha prevents rejection of islet xenografts (rat to mouse). Diabetes 42:651-7

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