The HCCC Analytical Pharmacology Laboratory is currently supported by HCCC, other research endowment funds, and contracts with cooperative groups for specific projects, but has no NIH funding as a Core facility. All the needed equipment is currently available. Support from the NCI for operating expenses will allow this facility to grow and support peer reviewed research exploring the effect of aging on the pharmacology of anti-neoplastic drugs as outlined in the """"""""Aging and Cancer Therapeutics"""""""" thematic area. An example of such research is the potential pilot study described that will be led by Dr. Shane Scott. The project explores whether cognitive changes in elderly subjects with breast cancer being treated with doxorubicin, cyclophosphamide and docetaxel are associated with cognitive changes associated with chemotherapy.
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| Weckmann, Michelle T; Gingrich, Roger; Mills, James A et al. (2012) Risk factors for delirium in patients undergoing hematopoietic stem cell transplantation. Ann Clin Psychiatry 24:204-14 |
| Zimmermann, Maike; Arachchige-Don, Aruni S; Donaldson, Michaela S et al. (2012) Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem 287:22838-53 |
| Svensson, Robert U; Haverkamp, Jessica M; Thedens, Daniel R et al. (2011) Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer. Am J Pathol 179:502-12 |
| McDowell, Bradley D; Wallace, Robert B; Carnahan, Ryan M et al. (2011) Demographic differences in incidence for pituitary adenoma. Pituitary 14:23-30 |
| Yager, Jeffrey R; Magnotta, Vincent A; Mills, James A et al. (2011) Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium. Psychiatry Res 191:128-32 |
| Beglinger, Leigh J; Mills, James A; Vik, Stacie M et al. (2011) The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients. Arch Clin Neuropsychol 26:98-109 |
| Robinson, Jennifer G; Booth, Benjamin (2010) Statin use and lipid levels in older adults: National Health and Nutrition Examination Survey, 2001 to 2006. J Clin Lipidol 4:483-90 |
| Robinson, Jennifer G; Ijioma, Nkechinyere; Harris, William (2010) Omega-3 fatty acids and cognitive function in women. Womens Health (Lond) 6:119-34 |
| Haring, Stuart J; Humphreys, Troy D; Wold, Marc S (2010) A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression. Nucleic Acids Res 38:846-58 |
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