) This is a planning and development (P20) grant proposal to add a Developing Program in Cancer and Aging (CAP) to the research activities of the University of Iowa (UI) Holden Comprehensive Cancer Center (HCCC). While all activities will take place within the HCCC, this is the product of a joint effort of that center with the UI Center on Aging, and results from a well-established strategic planning process from both centers. Based on that process, three scientific themes that build on existing institutional strength and needs have been chosen for development with the CAP: 1) Biology of aging and cancer [free radical biology]; 2) Co-morbidity [Effects of co-morbidity on clinical cancer outcomes]; and 3) Treatment efficacy and tolerance [chemotherapy pharmacology in older cancer patients]. Funds will be devoted to two core facilities identified by the strategic planning process: 1) a database core for providing health care analytical data for original studies of co-morbidity and other epidemiological investigations of older cancer patients; and 2) expanding analytical laboratory capacity for pharmaco-dynamic and -kinetic studies. In addition, we propose providing some funds for assisting in two targeted faculty recruitments related to chosen themes: in health services epidemiology (co-morbidity theme) and medical oncology/pharmacology (cancer therapeutics theme). Remaining activities include program administration, including ongoing planning and evaluation activities, and provision of variously sized pilot grants to promote research in the areas selected for development.
| Svensson, Robert U; Bannick, Nadine L; Marin, Maximo J et al. (2013) Chronic chlorpyrifos exposure does not promote prostate cancer in prostate specific PTEN mutant mice. J Environ Pathol Toxicol Oncol 32:29-39 |
| Zimmermann, Maike; Arachchige-Don, Aruni S; Donaldson, Michaela S et al. (2012) Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem 287:22838-53 |
| Weckmann, Michelle T; Gingrich, Roger; Mills, James A et al. (2012) Risk factors for delirium in patients undergoing hematopoietic stem cell transplantation. Ann Clin Psychiatry 24:204-14 |
| Svensson, Robert U; Haverkamp, Jessica M; Thedens, Daniel R et al. (2011) Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer. Am J Pathol 179:502-12 |
| McDowell, Bradley D; Wallace, Robert B; Carnahan, Ryan M et al. (2011) Demographic differences in incidence for pituitary adenoma. Pituitary 14:23-30 |
| Yager, Jeffrey R; Magnotta, Vincent A; Mills, James A et al. (2011) Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium. Psychiatry Res 191:128-32 |
| Beglinger, Leigh J; Mills, James A; Vik, Stacie M et al. (2011) The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients. Arch Clin Neuropsychol 26:98-109 |
| Robinson, Jennifer G; Booth, Benjamin (2010) Statin use and lipid levels in older adults: National Health and Nutrition Examination Survey, 2001 to 2006. J Clin Lipidol 4:483-90 |
| Robinson, Jennifer G; Ijioma, Nkechinyere; Harris, William (2010) Omega-3 fatty acids and cognitive function in women. Womens Health (Lond) 6:119-34 |
| Haring, Stuart J; Humphreys, Troy D; Wold, Marc S (2010) A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression. Nucleic Acids Res 38:846-58 |
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