The Mayo Clinic Cancer Center (MCCC) is a comprehensive cancer center that has been a designated NCI Center in Rochester, MN (MCR) since 1974. Today, MCCC includes not only MCR, but also sites in Jacksonville, Florida (MCF), and Scottsdale/Phoenix, Arizona (MCA). Each site has a thriving clinical cancer practice with clinical investigators at each of the sites, and a critical mass of basic science and population sciences faculty as well. In 2013, NCI recognized MCCC as an integrated comprehensive cancer based at all 3 sites, based on shared leadership, shared research including multi-investigator grant activity, co-author publications, and enterprise-wide clinical protocol activity. Robert B. Diasio, MD, has been director of MCCC since 2006, leading the center through successful competitive renewals of the CCSG application in 2008 and later in 2013. Since 2013, the center has continued to flourish with strong cancer-focused research, many examples of team science (e.g., SPOREs), an increase in high impact publications and many examples of translational research, and, most importantly, many examples of practice-changing approaches to cancer care. Following strategic planning in 2014, MCCC now has the following aims: 1. To advance the cancer-focused research of each of our MCCC members within our existing 10 Programs and within potential future Programs in order to promote high impact science. 2. To advance interactions of our MCCC members within Programs (intraprogrammatic); across Programs (interprogrammatic); and with individuals at other Cancer Centers and institutions (interinstitutional). 3. To advance new approaches for the treatment of cancer by facilitating translation of basic science concepts from the laboratory to the clinic within MCCC. 4. To continue to build and to further integrate cancer research activities at MCA, MCF, and MCR and to extend these activities to the Mayo Clinic Health System (MCHS). 5. To further develop cancer education for patients, high school, college, and graduate students, postgraduates, as well as faculty. 6. To extend our cancer research, practice, and education within our catchment areas at each of our 3 major sites in MCA, MCF, and MCR and the MCHS with the ultimate goal of lessening cancer burden. We will use these 6 specific aims to further the mission of MCCC: (1) to promote and facilitate research on the incidence, etiology, and molecular basis of cancer, and (2) through education and direct application of the results of such research, to translate the discoveries into improved methods for cancer prevention, detection, diagnosis, prognosis, and therapy.

Public Health Relevance

This Cancer Center Support Grant provides the infrastructure support to facilitate basic, clinical, and population sciences research relevant to cancer research conducted at the Mayo Clinic Cancer Center. The Center's ultimate goal is to lessen the cancer burden on patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA015083-45
Application #
9702998
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
He, Min
Project Start
1997-04-25
Project End
2024-02-29
Budget Start
2019-06-01
Budget End
2020-02-29
Support Year
45
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Dasari, Surendra; Newsom, Sean A; Ehrlicher, Sarah E et al. (2018) Remodeling of skeletal muscle mitochondrial proteome with high-fat diet involves greater changes to ?-oxidation than electron transfer proteins in mice. Am J Physiol Endocrinol Metab 315:E425-E434
Nowsheen, Somaira; Aziz, Khaled; Aziz, Asef et al. (2018) L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nat Cell Biol 20:455-464
Razidlo, Gina L; Burton, Kevin M; McNiven, Mark A (2018) Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42. J Biol Chem 293:11143-11153
Wu, Dongyan; Yang, Haitao; Winham, Stacey J et al. (2018) Mediation analysis of alcohol consumption, DNA methylation, and epithelial ovarian cancer. J Hum Genet 63:339-348
Leon-Ferre, Roberto A; Polley, Mei-Yin; Liu, Heshan et al. (2018) Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer. Breast Cancer Res Treat 167:89-99
Jahanseir, Khadijeh; Xing, Deyin; Greipp, Patricia T et al. (2018) PDGFB Rearrangements in Dermatofibrosarcoma Protuberans of the Vulva: A Study of 11 Cases Including Myxoid and Fibrosarcomatous Variants. Int J Gynecol Pathol 37:537-546
Painter, Jodie N; O'Mara, Tracy A; Morris, Andrew P et al. (2018) Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses. Cancer Med 7:1978-1987
Yu, Jia; Qin, Bo; Moyer, Ann M et al. (2018) DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine. J Clin Invest 128:2376-2388
Sugihara, Takaaki; Werneburg, Nathan W; Hernandez, Matthew C et al. (2018) YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity. Mol Cancer Res 16:1556-1567

Showing the most recent 10 out of 1129 publications