Abstract

The objectives of this proposal are to establish an Animal Disease Diagnostic and Investigatve Laboratory at the University of Miami. We will establish a comprehensive animal health surveillence program for breeding colonies, in house research colonies and suppliers. This proposal is a joint effort between the Division of Comparative Pathology and the Division of Veterinary Resources in the School of Medicine. The combined staff and facilities of these two divisions will pursue research projects based on case material submitted to the diagnostic laboratory and on important diseases in laboratory animal medicine. This proposal will also strengthen the teaching programs for graduate students and faculty who use animals in research as mandated by new NIH Guidelines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40RR004326-03
Application #
3103535
Study Section
Animal Resources Review Committee (AR)
Project Start
1988-04-01
Project End
1993-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146

  Publications

Emerson, C L; Wagner, J L (1996) Antibody responses to two encephalomyocarditis virus vaccines in rhesus macaques (Macaca mulatta). J Med Primatol 25:42-5
Hines 2nd, M E; Cray, C; Elvinger, F et al. (1996) Macrophage inhibitory factor-A3 derived from Mycobacterium avium serovar 2 inhibits candidacidal activity of murine peritoneal macrophages. Vet Microbiol 53:295-302
Cray, C; Mateo, M O; Altman, N H (1993) In vitro and long-term in vivo immune dysfunction after infection of BALB/c mice with mouse hepatitis virus strain A59. Lab Anim Sci 43:169-74
Hines 2nd, M E; Newton, J C; Altman, N H et al. (1993) Metastasizing extra-adrenal paraganglioma with neurological signs in four dogs. J Comp Pathol 108:283-90
Frazier, K S; Herron, A J; Hines 2nd, M E et al. (1993) Metastasis of a myxoid leiomyosarcoma via the renal and hepatic portal circulation in a sarus crane (Grus antigone). J Comp Pathol 108:57-63
Frazier, K S; Herron, A J; Hines 2nd, M E et al. (1993) Immunohistochemical and morphologic features of an intradermal nevocellular nevus (benign intradermal junctional melanocytoma) in a rhesus monkey (Macaca mulatta). Vet Pathol 30:306-8
Herron, A J; Brunnert, S R; Ching, S V et al. (1990) Immunohistochemical and morphologic features of chordomas in ferrets (Mustela putorius furo). Vet Pathol 27:284-6
Atherton, S S; Altman, N H; Streilein, J W (1989) Histopathologic study of herpes virus-induced retinitis in athymic BALB/c mice: evidence for an immunopathogenic process. Curr Eye Res 8:1179-92