This MHCRC will have as its major emphasis the study of schizophrenia and its related spectrum disorders. Its unifying concept will be the goal of linking the clinical picture of the illness with its underlying neurobiology. This CRC will be composed of seven research units. These units will conduct the integrative and interdisciplinary research that is needed to advance our knowledge concerning the clinical presentation of schizophrenia and its relation to pathophysiology, etiology, prevention, and treatment. The DIAGNOSIS AND PHENOMENOLOGY UNIT will examine clinical issues, including evaluation, nosology, longitudinal outcome, and instrument development. The BRAIN IMAGING UNIT will focus on structural and functional brain abnormalities, using CT scanning, MRI, SPECT, and PET; these studies will attempt to integrate our understanding of the clinical symptoms, such as hallucinations, with the neural mechanisms that underlie them. The GENETICS UNIT will take a comprehensive approach to the genetics of schizophrenia, using multiplex family studies, twin studies, adoption studies, and molecular genetics. Multiple biological measures will also be obtained in order to attempt to identify markers. The NEUROENDOCRINOLOGY UNIT will examine cortical-hypothalamic-pituitary-target organ axes in the major psychoses. The EPIDEMIOLOGY UNIT will explore mortality in schizophrenia, birth injury, and other risk factors; this unit will work closely with the GENETICS UNIT in order to examine the environmental side of the genetic versus environmental interaction. The BASIC NEUROBIOLOGY UNIT will conduct research on animal models of psychosis, with particular emphasis on neurochemical systems. The NEUROPHARMACOLOGY UNIT will pursue the study of pharmacokinetics, drug dosage, target symptoms, and side effects. Three CORE UNITS will support these research units: ADMINISTRATIVE, ASSESSMENT AND TRAINING, and BIOSTATISTICS. This MHCRC will build on existing resources at Iowa, such as an excellent clinical population, a strong research tradition, and established collaborative relationships with Radiology, Internal Medicine, Preventive Medicine, and Pharmacology. In addition, we will continue to place a major emphasis on the training of young investigators in research careers in schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH043271-02
Application #
3107202
Study Section
(SRCM)
Project Start
1987-09-30
Project End
1991-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Rudd, Danielle S; Axelsen, Michael; Epping, Eric A et al. (2014) A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. Am J Med Genet B Neuropsychiatr Genet 165B:619-26
Onwuameze, O E; Nam, K W; Epping, E A et al. (2013) MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse. Psychol Med 43:619-31
Andreasen, N C; Wilcox, M A; Ho, B-C et al. (2012) Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry 17:1093-102
Salinas, Joel; Mills, Elizabeth D; Conrad, Amy L et al. (2012) Sex differences in parietal lobe structure and development. Gend Med 9:44-55
Wassink, Thomas H; Epping, Eric A; Rudd, Danielle et al. (2012) Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Arch Gen Psychiatry 69:885-92
Andreasen, Nancy C; Nopoulos, Peg; Magnotta, Vincent et al. (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biol Psychiatry 70:672-9
Ho, Beng-Choon; Wassink, Thomas H; Ziebell, Steven et al. (2011) Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res 128:66-75
Ho, Beng-Choon; Andreasen, Nancy C; Ziebell, Steven et al. (2011) Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 68:128-37
Andreasen, Nancy C (2010) The lifetime trajectory of schizophrenia and the concept of neurodevelopment. Dialogues Clin Neurosci 12:409-15
Hartz, Sarah M; Ho, Beng-Choon; Andreasen, Nancy C et al. (2010) G72 influences longitudinal change in frontal lobe volume in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 153B:640-647

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