This MH-CRC has as its major emphasis the study of schizophrenia and related spectrum disorders. Its unifying concept is the goal of linking the clinical picture of the illness with its underlying neurobiology. The MH-CRC is composed of seven research units. These units conduct the integrative and interdisciplinary research that is needed to advance our knowledge concerning the clinical presentation of schizophrenia and its relation to pathophysiology, etiology, prevention and treatment. The Diagnosis and the Phenomenology Unit examines clinical issues, including evaluation, nosology, longitudinal outcome, and instrument development. The Brain Imaging Unit focuses on structural and functional brain abnormalities, using CT scanning, MRI, and SPECT; these studies attempt to integrate our understanding of the clinical symptoms, such as hallucinations, with the neural mechanisms that underlie them. The Genetics Unit takes a comprehensive approach to the genetics of schizophrenia, using multiplex family studies, twin studies, adoption studies, and molecular genetics. Multiple biological measures are obtained in order to identify markers. The Epidemiology Unit explores mortality in schizophrenia, birth history and other risk factors; this unit works closely with the Genetics unit in order to examine the environmental side of the genetic versus environmental interaction. The Basic Neurobiology Unit conducts research on animal models of psychosis and neurotransmitter systems assessed using both central and peripheral measures. The Neuropharmacology Unit pursues the study of pharmacokinetics, drug dosage, target symptoms, and side effects. The Neurophysiology/Neuropsychology Unit examines cognitive processing in psychosis and conducts studies using a variety of electrophysiological techniques. Three core units support these research units: Administrative, Assessment and Training, and Biostatistics. The Administrative Core Unit is responsible for maintaining a five-to six- bed inpatient unit on which patients can be studied after a three-week medication washout, as well as while on medications. This inpatient unit is crucial to the conduct of a majority of studies conducted by the MH-CRC, since an important goal is establishing the validity of neurobiological measures without contamination by neuroleptic effects. The Assessment and Training Unit insures that all assessment procedures are conducted in a reliable manner and provides training to investigators at Iowa and visitors from other facilities. The Biostatistics Core Unit maintains rigorous quality control over data management and provides consultation to investigators on experimental design and data analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
2P50MH043271-05
Application #
3107201
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1987-09-30
Project End
1994-08-31
Budget Start
1991-09-30
Budget End
1992-08-31
Support Year
5
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Rudd, Danielle S; Axelsen, Michael; Epping, Eric A et al. (2014) A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. Am J Med Genet B Neuropsychiatr Genet 165B:619-26
Onwuameze, O E; Nam, K W; Epping, E A et al. (2013) MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse. Psychol Med 43:619-31
Andreasen, N C; Wilcox, M A; Ho, B-C et al. (2012) Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry 17:1093-102
Salinas, Joel; Mills, Elizabeth D; Conrad, Amy L et al. (2012) Sex differences in parietal lobe structure and development. Gend Med 9:44-55
Wassink, Thomas H; Epping, Eric A; Rudd, Danielle et al. (2012) Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Arch Gen Psychiatry 69:885-92
Andreasen, Nancy C; Nopoulos, Peg; Magnotta, Vincent et al. (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biol Psychiatry 70:672-9
Ho, Beng-Choon; Wassink, Thomas H; Ziebell, Steven et al. (2011) Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res 128:66-75
Ho, Beng-Choon; Andreasen, Nancy C; Ziebell, Steven et al. (2011) Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 68:128-37
Andreasen, Nancy C (2010) The lifetime trajectory of schizophrenia and the concept of neurodevelopment. Dialogues Clin Neurosci 12:409-15
Hartz, Sarah M; Ho, Beng-Choon; Andreasen, Nancy C et al. (2010) G72 influences longitudinal change in frontal lobe volume in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 153B:640-647

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